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  1. No Access

    Article

    Strategies to improve public service activities in urban universities

    Some of the strategies utilized by universities to carry out the public service mission to their communities include cooperative extension, evening colleges, workshops and seminars, community forums, research ...

    Donald A. Deppe, David W. Hinton, John E. Kerrigan in The Urban Review (1979)

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    Chapter

    Proteinase 3: Substrate Specificity and Possible Pathogenetic Effect of Wegener’s Granulomatosis Autoantibodies (C-ANCA) by Dysregulation of the Enzyme

    Reactivity of proteinase 3 (PR3) was tested against various amino acid and thioester substrates. The best substrate is Boc-Ala-Ala-Nva-SBzl with a k cat/ ...

    Koert M. Dolman, Bart A. van de Wiel, Chih-Min Kam… in ANCA-Associated Vasculitides (1993)

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    Article

    Models of glycoprotein hormone receptor interaction

    The glycoprotein hormones regulate reproduction and development through their interactions with receptors in ovarian, testicular, and thyroid tissues. Efforts to design hormone agonists and antagonists useful ...

    William R. Moyle, Win Lin, Rebecca V. Myers, Donghui Cao, John E. Kerrigan… in Endocrine (2005)

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    Article

    Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes

    TSC1 acts coordinately with TSC2 in a complex to inhibit mTOR, an emerging therapeutic target and known promoter of cell growth and cell cycle progression. Perturbation of the mTOR pathway, through abnormal ex...

    Madhura S. Mehta, Alexei Vazquez… in Breast Cancer Research and Treatment (2011)

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    Protocol

    Molecular Dynamics Simulations in Drug Design

    This minireview focuses on recent developments in the application of molecular dynamics to drug design. Recent applications of endpoint free-energy computational methods such as molecular mechanics Poisson-Bol...

    John E. Kerrigan in In Silico Models for Drug Discovery (2013)

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    Protocol

    RNase H: Specificity, Mechanisms of Action, and Antiviral Target

    The Ribonuclease (RNase) H is one of the four enzymes encoded by all retroviruses, including HIV. Its main activity is the hydrolysis of the RNA moiety in RNA–DNA hybrids. The RNase H ribonuclease is essential...

    Karin Moelling, Felix Broecker, John E. Kerrigan in Human Retroviruses (2014)

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    Article

    Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer

    BMP receptor inhibitors induce death of cancer cells through the downregulation of antiapoptotic proteins XIAP, pTAK1, and Id1-Id3. However, the current most potent BMP receptor inhibitor, DMH2, does not downr...

    Jenna H. Newman, David J. Augeri, Rachel NeMoyer, Jyoti Malhotra… in Oncogene (2018)