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    Chapter

    Proteinase 3: Substrate Specificity and Possible Pathogenetic Effect of Wegener’s Granulomatosis Autoantibodies (C-ANCA) by Dysregulation of the Enzyme

    Reactivity of proteinase 3 (PR3) was tested against various amino acid and thioester substrates. The best substrate is Boc-Ala-Ala-Nva-SBzl with a k cat/ ...

    Koert M. Dolman, Bart A. van de Wiel, Chih-Min Kam… in ANCA-Associated Vasculitides (1993)

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    Chapter

    Serine Protease Control of Lymphocyte-Mediated Cytolysis

    Serine proteases initiate several complex biochemical responses to sudden, life-threatening situations. The immediate and localized activation of coagulant serine proteases prevents mammals from bleeding to de...

    Dorothy Hudig, N. Janine Allison… in Cytotoxic Cells: Recognition, Effector Fun… (1993)

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    Chapter

    Synthetic Substrates and Inhibitors of Thrombin

    Thrombin has a central regulatory role in hemostasis and is formed by both the intrinsic and extrinsic pathways of blood coagulation (Fenton, 1986, 1981). The major function of this serine protease is the clea...

    James C. Powers, Chih-Min Kam in Thrombin (1992)