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Article
Open AccessHLA-DRB1 haplotypes predict cardiovascular mortality in inflammatory polyarthritis independent of CRP and anti-CCP status
Haplotypes defined by amino acids at HLA-DRB1 positions 11, 71 and 74 associated with susceptibility to rheumatoid arthritis (RA) are associated with radiological outcome, anti-TNF response and all cause-morta...
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Article
Open AccessApplication of information theoretic feature selection and machine learning methods for the development of genetic risk prediction models
In view of the growth of clinical risk prediction models using genetic data, there is an increasing need for studies that use appropriate methods to select the optimum number of features from a large number of...
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Article
Open AccessGenetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases
Genome-wide association studies (GWAS) have identified pervasive sharing of genetic architectures across multiple immune-mediated diseases (IMD). By learning the genetic basis of IMD risk from common diseases,...
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Open AccessMolecular insights into genome-wide association studies of chronic kidney disease-defining traits
Genome-wide association studies (GWAS) have identified >100 loci of chronic kidney disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations remain elusive. Using 280 kidney transcri...
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Open AccessMajor histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis
Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a two-stage approach to make vGWAS a...
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Correction: Corrigendum: Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
Nat. Genet. 47, 839–846 (2015); published online 8 June 2015; corrected after print 8 July 2015 In the version of this article initially published, the two panels in Figure 2 were presented in the incorrect or...
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Correction: Corrigendum: Dense genoty** of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Nature Communications 6: Article number: 6046 (2015); Published 5 February 2015; Updated 6 July 2015 The affiliation details for Emiliano Giardina are incorrect in this Article. The correct address for this au...
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Open AccessDense genoty** of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis and, despite the larger estimated heritability for PsA, the majority of genetic susceptibility loci identified to date ar...
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Article
Open AccessRare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis
Genome-wide association studies (GWAS) conducted using commercial single nucleotide polymorphisms (SNP) arrays have proven to be a powerful tool for the detection of common disease susceptibility variants. How...
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Open AccessOverlap** genetic susceptibility variants between three autoimmune disorders: rheumatoid arthritis, type 1 diabetes and coeliac disease
Genome wide association studies, replicated by numerous well powered validation studies, have revealed a large number of loci likely to play a role in susceptibility to many multifactorial diseases. It is now ...
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Erratum to: Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?
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Open AccessAssociation of the FCRL3gene with rheumatoid arthritis: a further example of population specificity?
Association of a functional promoter polymorphism map** to the Fc receptor-like 3 (FCRL3) gene has recently been reported and replicated with rheumatoid arthritis (RA) in Japanese populations. The aim of this s...
