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Article
Open AccessProtection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent mo...
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Article
Open AccessPerformance of the Alere i RSV assay for point-of-care detection of respiratory syncytial virus in children
Respiratory syncytial virus (RSV) is the most important cause of severe acute respiratory tract infection in young children. Alere i RSV is a novel molecular rapid test which identifies respiratory syncytial v...
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Protocol
High-Density Peptide Arrays for Malaria Vaccine Development
The development of an efficacious and practicable vaccine conferring sterile immunity towards a Plasmodium infection represents a not yet achieved goal. A crucial factor for the impact of a given anti-plasmodial ...
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Article
Open AccessAddition of histamine to subcutaneously injected Plasmodium berghei sporozoites increases the parasite liver load and could facilitate whole-parasite vaccination
Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration,...
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Article
Open AccessNewborn screening by tandem mass spectrometry for glutaric aciduria type 1: a cost-effectiveness analysis
Glutaric aciduria type I (GA-I) is a rare metabolic disorder caused by inherited deficiency of glutaryl-CoA dehydrogenase. Despite high prognostic relevance of early diagnosis and start of metabolic treatment ...
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Article
Open AccessContinuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models
Chloroquine (CQ) is utilized as both cure and prophylaxis to Plasmodium infection. In animal studies, CQ administration to experimental animals is via intraperitoneal (i.p.) injection of a single dose that varies...
