10 Result(s)
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Ann-Kristin Mueller
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Article
Inhibition of EIF-5A prevents apoptosis in human cardiomyocytes after malaria infection
In this study, a determination of Troponin I and creatine kinase activity in whole-blood samples in a cohort of 100 small infants in the age of 2–5 years from Uganda with complicated Plasmodium falciparum malaria...
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Open AccessProtection from experimental cerebral malaria with a single intravenous or subcutaneous whole-parasite immunization
Cerebral malaria is a life-threatening complication of Plasmodia infection and a major cause of child mortality in Sub-Saharan Africa. We report that protection from experimental cerebral malaria in the rodent mo...
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Whole-Sporozoite Malaria Vaccines
Whole-sporozoite administration is the sole immunization strategy that has been shown to elicit sterile immunity against malaria. Sporozoite-based immunization aims at eliciting potent pre-erythrocytic immune ...
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Open AccessOxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
Plasmodium falciparum infections can cause severe malaria, but not every infected person develops life-threatening complications. In particular, carriers of the structural haemoglobinopathies S and C and infants ...
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Open AccessProtective efficacy and safety of liver stage attenuated malaria parasites
During the clinically silent liver stage of a Plasmodium infection the parasite replicates from a single sporozoite into thousands of merozoites. Infection of humans and rodents with large numbers of sporozoites ...
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Open AccessZinc finger nuclease-based double-strand breaks attenuate malaria parasites and reveal rare microhomology-mediated end joining
Genome editing of malaria parasites is key to the generation of live attenuated parasites used in experimental vaccination approaches. DNA repair in Plasmodium generally occurs only through homologous recombinati...
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Open AccessAddition of histamine to subcutaneously injected Plasmodium berghei sporozoites increases the parasite liver load and could facilitate whole-parasite vaccination
Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration,...
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Open AccessIn vitro and in vivo silencing of plasmodial dhs and eIf-5a genes in a putative, non-canonical RNAi-related pathway
Deoxyhypusine synthase (DHS) catalyzes the first step in hypusine biosynthesis of eukaryotic initiation factor 5A (eIF-5A) in Plasmodium falciparum. Target evaluation of parasitic DHS has recently been performed ...
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Open AccessContinuous oral chloroquine as a novel route for Plasmodium prophylaxis and cure in experimental murine models
Chloroquine (CQ) is utilized as both cure and prophylaxis to Plasmodium infection. In animal studies, CQ administration to experimental animals is via intraperitoneal (i.p.) injection of a single dose that varies...
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Genetically modified Plasmodium parasites as a protective experimental malaria vaccine
The prospect of large-scale production of an effective malaria vaccine comes a step closer with publication of a study showing that a vaccine made from a live malaria parasite can protect against infection in ...
