133 Result(s)
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Johannes Hebebrand
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Article
Open AccessNo evidence for a causal contribution of bioavailable testosterone to ADHD in sex-combined and sex-specific two-sample Mendelian randomization studies
The higher prevalence of attention-deficit/hyperactivity disorder (ADHD) in males raises the question of whether testosterone is implicated in ADHD risk. However, cross-sectional studies did not identify an as...
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Open AccessUnexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa
Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (MC4R) gen...
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The 2023 ESCAP Research Academy workshop: ADHD and emotional dysregulation
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Chapter
Eating Disorders in the ICD-11 and DSM-5
The transition to the eleventh revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-11) entails significant innovations for the chapter on eating disorders. By ...
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Open AccessCase report: clinical improvements observed in first off-label metreleptin treatment of a patient with atypical anorexia nervosa
Off-label metreleptin treatment resulted in cognitive, emotional and behavioral improvements of patients with anorexia nervosa, who presented with hypoleptinemia. We now report a case study of a 16-year-old fe...
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Article
Could leptin substitution therapy potentially terminate entrapment in anorexia nervosa?
Case studies of patients with anorexia nervosa revealed psychological improvements upon treatment with recombinant human leptin, including an alleviation of the entrapment in this eating disorder. Hypoleptinae...
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Open AccessEvaluation of the MC3R gene pertaining to body weight and height regulation and puberty development
Recent studies reported an impact of the melanocortin 3 receptor (MC3R) on the regulation of body weight, linear growth and puberty timing. Previously, allele p.44Ile of a frequent non-synonymous variant (NSV)...
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Open AccessIdentifying Symptoms of ADHD and Disruptive Behavior Disorders Most Strongly Associated with Functional Impairment in Children: A Symptom-Level Approach
To enhance the understanding of how symptoms of attention-deficit/hyperactivity disorder (ADHD) and disruptive behavior disorders such as oppositional defiant disorder (ODD), conduct disorder (CD), including c...
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Perceived impact of the COVID-19 pandemic on child and adolescent psychiatric services after 1 year (February/March 2021): ESCAP CovCAP survey
In April 2020, the European Society for Child and Adolescent Psychiatry (ESCAP) Research Academy and the ESCAP Board launched the first questionnaire of the CovCAP longitudinal survey to estimate the impact of...
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The 2022 ESCAP Research Academy Workshop: New Perspectives on Eating Disorders
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Article
Open AccessThe importance of familial risk factors in children with ADHD: direct and indirect effects of family adversity, parental psychopathology and parenting practices on externalizing symptoms
Children experiencing unfavorable family circumstances have an increased risk of develo** externalizing symptoms. The present study examines the direct, indirect and total effects of family adversity, parent...
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Correction to: Next generation Europe: a recovery plan for children, adolescents and their families
A correction to this paper has been published: https://doi.org/10.1007/s00787-021-01801-x
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Correction to: ESCAP CovCAP survey of heads of academic departments to assess the perceived initial (April/May 2020) impact of the COVID-19 pandemic on child and adolescent psychiatry services
A correction to this paper has been published: https://doi.org/10.1007/s00787-021-01754-1
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Open AccessRapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism
With this case report we support our medical hypothesis that metreleptin treatment ameliorates starvation related emotional, cognitive and behavioral symptomatology of anorexia nervosa (AN) and show for the fi...
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Open AccessEvidence for correlations between BMI-associated SNPs and circRNAs
Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment o...
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Open AccessThe bidirectional relationship of obesity and labor market status - Findings from a German prospective panel study
Given the inconsistent findings regarding associations between obesity and unemployment, our analysis is one of the few that explores bidirectional changes in obesity and unemployment. In our prospective study...
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Article
Open AccessThe adrenal steroid profile in adolescent depression: a valuable bio-readout?
There is preliminary evidence that adrenal steroids other than cortisol may be valuable biomarkers for major depressive disorder (MDD). So far, studies have been conducted in adults only, and conclusions are l...
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Open AccessPTBP2 – a gene with relevance for both Anorexia nervosa and body weight regulation
Genetic factors are relevant for both eating disorders and body weight regulation. A recent genome-wide association study (GWAS) for anorexia nervosa (AN) detected eight genome-wide significant chromosomal loc...
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Editorial statement
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Article
Open AccessLow leptin levels are associated with elevated physical activity among lean school children in rural Tanzania
In Sub-Saharan African countries, rapid urbanization and increasing socio-economic status are associated with a transition to decreased physical activity (PA). A more sedentary lifestyle is linked to increased...
