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Article
Krüppel-like factors: potential roles in blood-brain barrier dysfunction and epileptogenesis
Epilepsy is a chronic and debilitating neurological disorder, known for the occurrence of spontaneous and recurrent seizures. Despite the availability of antiseizure drugs, 30% of people with epilepsy experien...
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Article
Open AccessAmorphous nasal powder advanced performance: in vitro/ex vivo studies and correlation with in vivo pharmacokinetics
Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to increase drug release performance, while using polymers with mucoadhesive properties. The aim of the present study was to apply thi...
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Article
Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
Zonisamide clinical indications are expanding beyond the classic treatment of epileptic seizures to Parkinson’s disease and other neurodegenerative diseases. However, the systemic safety profile of zonisamide ...
