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Article
Open AccessNeuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models
Retinal ischemia/reperfusion (RIR) is implicated in various forms of optic neuropathies, yet effective treatments are lacking. RIR leads to the death of retinal ganglion cells (RGCs) and subsequent vision loss...
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Article
Open AccessWhole genome sequencing enables new genetic diagnosis for inherited retinal diseases by identifying pathogenic variants
Inherited retinal diseases (IRDs) are a group of common primary retinal degenerative disorders. Conventional genetic testing strategies, such as panel-based sequencing and whole exome sequencing (WES), can onl...
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Article
Open AccessEvaluation of the Glaucomatous Macular Damage by Chromatic Pupillometry
This study aimed to examine the performance of binocular chromatic pupillometry for the objective and rapid detection of primary open-angle glaucoma (POAG), and to explore the association between pupillary lig...
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Article
A Genome-Wide Association Study for Susceptibility to Axial Length in Highly Myopic Eyes
High myopia has long been highly prevalent worldwide with a largely yet unexplained genetic contribution. To identify novel susceptibility genes for axial length (AL) in highly myopic eyes, a genome-wide assoc...
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Article
Open AccessVolume-accumulated reflectivity of the outer retina (integral) on spectral domain optical coherence tomography as a predictor of cone cell density: a pilot study
The study aims to investigate the relationship between the volume-accumulated reflectivity (termed “integral”) on spectral domain optical coherence tomography (SD-OCT) and cone density on adaptive optics (AO) ...
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Article
Open AccessTaurine protects R28 cells from hypoxia/re-oxygenation-induced damage via regulation of mitochondrial energy metabolism
Oxidative-induced damage and hypoxia/re-oxygenation (H/R) injury are common causes of irreversible visual impairment. The goals of this study were to explore the effects of taurine on R28 cells under the two d...
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Leber Hereditary Optic Neuropathy
A 22-year-old female sophomore college student complained of acute bilateral vision loss for 1 month. Prior to the vision problem, she was busy preparing for the examinations and stayed late often. She denied ...
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Article
Open AccessSingle cell atlas for 11 non-model mammals, reptiles and birds
The availability of viral entry factors is a prerequisite for the cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Large-scale single-cell screening of animal cells c...
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Article
Open AccessTRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway
Glaucoma, the leading cause of irreversible blindness worldwide, is a type of retinal disease characterized by the selective death of retinal ganglion cells (RGCs). However, the pathogenesis of glaucoma has no...
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Article
Open AccessThe mutation spectrum in familial versus sporadic congenital cataract based on next-generation sequencing
Congenital cataract (CC) is a significant cause of lifelong visual loss, and its genetic diagnosis is challenging due to marked genetic heterogeneity. The purpose of this article is to report the genetic findi...
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Article
Identification and Antioxidant Activity of a Novel Peptide from Baijiu
A novel peptide, Cys-Trp-Cys (CWC), which firstly isolated from Guo**g Baijiu was qualitative and quantitative studied by high-performance liquid chromatography and quadrupole-time-of-flight-mass spectrometry...
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Article
Study on photofading of two natural dyes sodium copper chlorophyllin and gardenia yellow on cotton
The light fastness of fabrics dyed with natural dyes is not satisfactory, which limits their applications in the textile industry. So far, the detailed photofading mechanism of natural dyes remains unclear. To...
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Article
Open AccessNumerical evaluation of spray position for improved nasal drug delivery
Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity in instructions show a lack of definitive knowledg...
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Article
Mussel-inspired fabrication of superhydrophobic cotton fabric for oil/water separation and visible light photocatalytic
Flexible multiple functional textiles for oil/water separation and photodegradation are highly demanded in highly effective and environmentally friendly wastewater purification. In this work, β-FeOOH nanorods ...
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Article
Open AccessNovel mutations and the ophthalmologic characters in Chinese patients with Wolfram Syndrome
Wolfram Syndrome (WFS) is a rare autosomal recessive neurodegenerative disease which has a wide spectrum of manifestations including diabetes insipidus, diabetes mellitus, optic atrophy and deafness. WFS1 and CIS...
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Article
Polydopamine-assisted immobilization of Ag@AuNPs on cotton fabrics for sensitive and responsive SERS detection
Depositing anisotropic noble metal nanoparticles with high uniformity and yield on flexible substrates is the determining factor for surface enhanced Raman spectroscopy (SERS) detection. In this work, flexibl...
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Article
Open AccessA novel mutation in the OAR domain of PITX3 associated with congenital posterior subcapsular cataract
Congenital cataract is the most common cause of blindness among children worldwide. The aim of this study was to identify causative mutations in a Chinese family with isolated autosomal dominant posterior subc...
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Article
Durable UV-protective cotton fabric by deposition of multilayer TiO2 nanoparticles films on the surface
Durable ultraviolet (UV)-protective cotton fabric has great application potential in outdoor cotton clothing. In this study, oppositely charged TiO2 nanoparticles were deposited onto cotton fabric through the lay...
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Article
In situ reduction of TiO2 nanoparticles on cotton fabrics through polydopamine templates for photocatalysis and UV protection
In this work, titanium dioxide (TiO2) nanoparticles were immobilized on the surface of cotton fabrics by in situ reduction on polydopamine (PDA) templates. Evidenced by the results of scanning electron microscopy...
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Article
UV protective PET nanocomposites by a layer-by-layer deposition of TiO2 nanoparticles
The oppositely charged titanium dioxide (TiO2) nanoparticles were deposited on the surface of poly(ethylene terephthalate) (PET) substrates by a layer-by-layer (LBL) assembly method. The PET films were pretreated...
