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Open AccessHagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences
Polyploidy or whole-genome duplication (WGD) is a major event that drastically reshapes genome architecture and is often assumed to be causally associated with organismal innovations and radiations. The 2R hyp...
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Article
Open AccessAuthor Correction: Genomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms
A Correction to this paper has been published: https://doi.org/10.1038/s42003-021-02005-4
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Article
Open AccessGenomic insights of body plan transitions from bilateral to pentameral symmetry in Echinoderms
Echinoderms are an exceptional group of bilaterians that develop pentameral adult symmetry from a bilaterally symmetric larva. However, the genetic basis in evolution and development of this unique transformat...
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Article
Open AccessRecapitulation-like developmental transitions of chromatin accessibility in vertebrates
The relationship between development and evolution has been a central theme in evolutionary developmental biology. Across the vertebrates, the most highly conserved gene expression profiles are found at mid-em...
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Article
Open AccessEmbryonic lethality is not sufficient to explain hourglass-like conservation of vertebrate embryos
Understanding the general trends in developmental changes during animal evolution, which are often associated with morphological diversification, has long been a central issue in evolutionary developmental bio...
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Constrained vertebrate evolution by pleiotropic genes
Despite morphological diversification of chordates over 550 million years of evolution, their shared basic anatomical pattern (or ‘bodyplan’) remains conserved by unknown mechanisms. The developmental hourglas...
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Open AccessEvolutionary acquisition of promoter-associated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals
Recent transcriptome analyses have shown that long non-coding RNAs (ncRNAs) play extensive roles in transcriptional regulation. In particular, we have reported that promoter-associated ncRNAs (pancRNAs) activa...
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Open AccessBidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals
The majority of non-coding RNAs (ncRNAs) involved in mRNA metabolism in mammals have been believed to downregulate the corresponding mRNA expression level in a pre- or post-transcriptional manner by forming sh...