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Article
Open AccessCDK4/6 inhibitors dephosphorylate RNF26 to stabilize TSC1 and increase the sensitivity of ccRCC to mTOR inhibitors
The combined use of CDK4/6 inhibitors and mTOR inhibitors has achieved some clinical success in ccRCC. Exploring the underlying mechanism of the CDK4/6 pathway in cancer cells and the drug interactions of CDK4...
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Article
Open AccessA novel predictive model of microvascular invasion in hepatocellular carcinoma based on differential protein expression
This study aims to construct and verify a nomogram model for microvascular invasion (MVI) based on hepatocellular carcinoma (HCC) tumor characteristics and differential protein expressions, and explore the cli...
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Article
Open AccessLow-dose celecoxib-loaded PCL fibers reverse intervertebral disc degeneration by up-regulating CHSY3 expression
Intervertebral disc degeneration (IDD) has been identified as one of the predominant factors leading to persistent low back pain and disability in middle-aged and elderly people. Dysregulation of Prostaglandin...
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Article
Mobile edge computing task distribution and offloading algorithm based on deep reinforcement learning in internet of vehicles
Mobile edge computing has been deeply integrated with internet of vehicles (IoV) due to its efficient computing capabilities close to devices. However, the inefficiency of storage and computing capabilities fo...
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Article
A Computing Resource Allocation Optimization Strategy for Massive Internet of Health Things Devices Considering Privacy Protection in Cloud Edge Computing Environment
With the development of 5G and the explosive growth of massive Internet of Health Things devices, existing computing resource allocation strategies have many problems such as long delay and poor security perfo...
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Article
Ballast Mechanical Performance with and without Under Sleeper Pads
With the train speed and axle load increasing, excessive stresses are produced and transmitted to the ballast layer, inducing rapid ballast degradation. To solve this issue, the under sleeper pads (USPs) have ...
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Article
Analysis of Damage of Joints in CRTSII Slab Track under Temperature and Vehicle Loads
Damage in joints has a significant effect on the integrity and stability of the China Railway Track System (CRTS)II slab track. In this study, a three-dimensional finite element model was established to invest...
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Article
Open AccessNrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration
Intervertebral disc (IVD) degeneration is known to aggravate with age and oxidative stress is implicated in the pathogenesis of many age-related diseases. Nuclear factor (erythroid-derived-2)-like 2 (Nrf2) can...
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Article
Open AccessEstrogen receptor α-NOTCH1 axis enhances basal stem-like cells and epithelial-mesenchymal transition phenotypes in prostate cancer
Prostate cancer (PCa) is the second leading cause of mortality and a leading cause of malignant tumors in males. Prostate cancer stem cells (PCSCs) are likely the responsible cell types for cancer initiation, ...
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Chapter and Conference Paper
Attitudes Toward Autonomous on Demand Mobility System: The Case of Self-Driving Taxi
Self-driving cars are ready to serve customers, but previous studies found that the general public is still cautious to ride in autonomous vehicles. This study investigated the influence of attitude and trust ...
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Article
A near-infrared fluorescent probe based on chloroacetate modified naphthofluorescein for selectively detecting cysteine/homocysteine and its application in living cells
We have prepared a near-infrared (NIR) turn-on fluorescent probe (NFC) based on chloroacetate modified naphthofluorescein for specific detection of cysteine (Cys) and homocysteine (Hcy) over glutathione (GSH) and...
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Article
MiR-34a promotes Fas-mediated cartilage endplate chondrocyte apoptosis by targeting Bcl-2
Apoptosis of cartilage endplate (CEP) chondrocytes is associated with the pathogenesis of intervertebral disk degeneration (IDD). Recent studies have shown that miR-34a is crucially involved in chondrocyte apo...
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Article
Open AccessCharacterization and expression of Rubisco activase genes in Ipomoea batatas
Two-dimensional electrophoresis, coupled with MALDI-TOF-MS, was used to identify differentially expressed proteins between young and mature leaves of sweet potato [Ipomoea batatas (L.) Lam]. The results showed th...
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Article
A proteomic analysis of storage stress responses in Ipomoea batatas (L.) Lam. tuberous root
During post-harvest storage, tuberous roots of sweet potato (Ipomoea batatas L. Lam.) usually undergo a biotic and abiotic stress influencing protein expression pattern and substance contents. This research compa...
