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Article
Open AccessIKBIP promotes tumor development via the akt signaling pathway in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide. Inhibitor of kappa B kinase interacting protein (IKBIP) has been reported to promote glioma progression, but its role in o...
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Article
Open AccessGeneralizable transcriptome-based tumor malignant level evaluation and molecular subty** towards precision oncology
In cancer treatment, therapeutic strategies that integrate tumor-specific characteristics (i.e., precision oncology) are widely implemented to provide clinical benefits for cancer patients. Here, through in-de...
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Article
Open AccessEffect isolated lactic acid bacteria inoculation on the quality, bacterial composition and metabolic characterization of Caragana korshinskii silage
Feed shortage has hindered the development of the world’s livestock industry, and the rational use of non-conventional forages can help resolve this issue. To improve the fermentation quality of Caragana korshins...
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Article
Nanocellulose-based composite beads as the amphoteric adsorbent for effective adsorption of cationic and anionic dyes
Treating water pollution, especially dye-contaminated wastewater, in an economical and efficient manner remains a challenge as the surface charge diversity of contaminants. This work designed a nanocellulose-b...
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Article
Field Tests of the Horizontal Freezing Method for Shield Tunneling in Complex Sites
To study the freezing characteristics and the effects of the horizontal freezing method of shield tunneling on the surrounding environment at a complex site, a systematic study with field measurements of the t...
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Article
Nanocellulose/polypyrrole hydrogel scaffolds with mechanical strength and electrical activity matching native cardiac tissue for myocardial tissue engineering
Tissue engineering offers a promising alternative therapy for myocardial infarction, which is associated with high mortality rates. Meanwhile, excellent biocompatibility and conductivity are indispensable feat...
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Article
Comparison of thermal shock resistance capabilities of the rotary swaged pure tungsten, potassium-doped tungsten, and W-La2O3 alloys
Tungsten-based materials are one of the most important candidates for the plasma facing materials (PFMs) of future fusion reactors, and it is necessary to study the properties of tungsten-based materials under...
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Article
Open AccessCalifornia dominates U.S. emissions of the pesticide and potent greenhouse gas sulfuryl fluoride
Sulfuryl fluoride (SO2F2) is a synthetic pesticide and a potent greenhouse gas that is accumulating in the global atmosphere. Rising emissions are a concern since SO2F2 has a relatively long atmospheric lifetime ...
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Article
Super capacity of ligand-engineered biochar for sorption of malachite green dye: key role of functional moieties and mesoporous structure
This study synthesized a new thiomalic acid–modified rice husk biochar (TMA-BC) as a versatile and eco-friendly sorbent. After undergoing chemical treatments, the mercerized rice husk biochar (NaOH-BC) and TMA...
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Article
Open AccessInfluence of thermal maturity on carbazole distributions in coal source rocks during compaction pyrolysis experiments
Carbazole compounds are widely used in determining the direction of petroleum migration, but the effect of thermal maturity on carbazoles is still ambiguity. In this paper, using compaction pyrolysis simulatio...
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Article
Open AccessFacile synthesis of Gd/Ru-doped fluorescent carbon dots for fluorescent/MR bimodal imaging and tumor therapy
Functional metal do** endows fluorescent carbon dots with richer physical and chemical properties, greatly expanding their potential in the biomedical field. Nonetheless, fabricating carbon dots with integra...
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Article
Synthesis of carbon dots with predictable photoluminescence by the aid of machine learning
Carbon dots (CDs) have wide application potentials in optoelectronic devices, biology, medicine, chemical sensors, and quantum techniques due to their excellent fluorescent properties. However, synthesis of CD...
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Article
Open AccessExploration of subgroups and predictors of loneliness among older adults in rural China: A latent profile analysis
Loneliness is a negative emotional state that can lead to physical and mental health problems. This study’s objective was to acquire an in-depth understanding of the heterogeneity and the predictors of lonelin...
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Article
Open AccessElevated extracellular matrix protein 1 in circulating extracellular vesicles supports breast cancer progression under obesity conditions
The cargo content in small extracellular vesicles (sEVs) changes under pathological conditions. Our data shows that in obesity, extracellular matrix protein 1 (ECM1) protein levels are significantly increased ...
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Article
Open AccessMZ1, a BRD4 inhibitor, exerted its anti-cancer effects by suppressing SDC1 in glioblastoma
Glioblastoma (GBM) is a relatively prevalent primary tumor of the central nervous system in children, characterized by its high malignancy and mortality rates, along with the intricate challenges of achieving ...
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Article
Open AccessAnalysis of forage quality, volatile organic compounds and metabolic pathways in alfalfa (Medicago sativa L.) at different stages based on electronic nose and GC-MS
The odor of alfalfa (Medicago sativa L.), the most extensively cultivated forage, can interfere with livestock feeding. This study used an electronic nose in conjunction with gas chromatography–mass spectrometry ...
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Article
Experimental Research on Bearing Behaviors of Cement Mortar-Expanded Precast Piles
Cement mortar-expanded precast (CMEP) piles comprise a new class of expansion pile technology. To reveal their vertical bearing properties, full-scale research on the bearing performance of expanded piles unde...
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Article
Open AccessEfficacy of sensory-based static balance training on the balance ability, aging attitude, and perceived stress of older adults in the community: a randomized controlled trial
This study explores the effect of sensory-based static balance training on the balance ability, aging attitude, and perceived stress of older adults in the community. It provides a practical basis for the in-d...
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Article
Morphology and Stoichiometry Dependent Electrocatalytic Activity of Cu2ZnSnS4 for Hydrogen Evolution Reaction (HER) with Addition of Nonionic Surfactants
In this work, hierarchical Cu2ZnSnS4 electrocatalysts with different morphologies and stoichiometries were synthesized via the hydrothermal method and their electrocatalytic performances in hydrogen evolution rea...
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Article
P25/CDK5-mediated Tau Hyperphosphorylation in Both Ipsilateral and Contralateral Cerebra Contributes to Cognitive Deficits in Post-stroke Mice
Post-stroke cognitive impairment (PSCI) develops in approximately one-third of stroke survivors and is associated with ingravescence. Nonetheless, the biochemical mechanisms underlying PSCI remain unclear. The...
