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Article
Open AccessMZ1, a BRD4 inhibitor, exerted its anti-cancer effects by suppressing SDC1 in glioblastoma
Glioblastoma (GBM) is a relatively prevalent primary tumor of the central nervous system in children, characterized by its high malignancy and mortality rates, along with the intricate challenges of achieving ...
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Article
The locust plagues in the Yangtze River Delta of China during the Ming and Qing Dynasties
The Little Ice Age was concurrent with frequent natural disasters in China during the Ming and Qing Dynasties (1368–1911 AD). Using historical documents created in the Yangtze River Delta during these dynastie...
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Article
Bimetallic FeMn@C derived from Prussian blue analogue as efficient nanozyme for glucose detection
In recent decades, nanomaterial-based artificial enzymes called nanozymes have received more and more attention and have been applied in biological, chemical, medical, and other fields. In this work, bimetalli...
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Article
Open AccessSuper-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma
Abnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an important role in neuroblastoma. We recently discovered that the insul...
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Article
Open AccessTh cytokine profile in childhood-onset systemic lupus erythematosus
Childhood-onset systemic lupus erythematosus (cSLE) is a kind of chronic inflammatory disease characterized by a highly abnormal immune system. This study aimed to detect the serum levels of Th (T helper) cyto...
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Article
Open AccessSignificance of sTREM-1 in early prediction of ventilator-associated pneumonia in neonates: a single-center, prospective, observational study
To evaluate whether soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) can be used as an early predictor of ventilator-associated pneumonia (VAP).
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Article
MiR-4465 directly targets PTEN to inhibit AKT/mTOR pathway–mediated autophagy
Autophagy plays an important role in maintaining cell function. Abnormal autophagy leads to cell dysfunction and is associated with many diseases such as tumors, immunodeficiency diseases, lysosomal storage di...
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Article
Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway
Bis(propyl)-cognitin (B3C), derived from tacrine linked with three methylene (–CH2–) groups, is a dimerized molecule interacting multiple targets. During the past several years, it has been reported as a promi...
