1,010 Result(s)

Article

A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neur...

**xi Guo, **aosa Zhao, ** Lu, Li** Zhao… in Signal Transduction and Targeted Therapy (2024)

Article

Clinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma

Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data sh...

Yanni Wang, Chang Liu, Huan Chen, ** Jiao… in Signal Transduction and Targeted Therapy (2024)

Article

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. ...

Yuzheng Zhou, Zongpeng Chen, Sijie Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection

This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explo...

Wen**g Zai, Min Yang, Kuan Jiang, Juan Guan… in Signal Transduction and Targeted Therapy (2024)

Article

Penpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study

Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining effi...

**aozhong Chen, Wei Wang, Qingfeng Zou… in Signal Transduction and Targeted Therapy (2024)

Article

Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II–III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study

This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II–III non-small-cell l...

Haoran **a, Han Zhang, Zheng Ruan… in Signal Transduction and Targeted Therapy (2024)

Article

Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no approved RSV-specific therapeutic small molecules available. Using ...

Qi Yang, Bao Xue, Fengjiang Liu, Yongzhi Lu… in Signal Transduction and Targeted Therapy (2024)

Article

Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. I...

Sihui Luo, Xueying Zheng, Wei Bao, Sheng Nie… in Signal Transduction and Targeted Therapy (2024)

Article

Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor efficacy. Targeted radionuclide therapy delivers radiation directly to tumor sites. LNC1004 is a fibroblast a...

Liang Zhao, Yizhen Pang, Yangfan Zhou… in Signal Transduction and Targeted Therapy (2024)

Article

Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain uncl...

Gang Yang, **peng Cao, Jian Qin, **nyue Mei… in Signal Transduction and Targeted Therapy (2024)

Article

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are tran...

Qingmiao Shi, Chen Xue, Yifan Zeng, **n Yuan… in Signal Transduction and Targeted Therapy (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities

Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment, but challenges related to resistance and toxicity still remain. Due to the advancement of immuno-oncolo...

Nanhao Yin, **ntong Li, Xuanwei Zhang… in Signal Transduction and Targeted Therapy (2024)

Article

Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain

Almost all the neutralizing antibodies targeting the receptor-binding domain (RBD) of spike (S) protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerg...

Bo Liu, Honghui Liu, Pu Han, **aoyun Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention

Previous studies have shown that low platelet count combined with high plasma total homocysteine (tHcy) increased stroke risk and can be lowered by 73% with folic acid. However, the combined role of other plat...

Yuncong Shi, Zhengzhipeng Zhang, Binyan Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies

Xun Wang, Shujun Jiang, Wentai Ma… in Signal Transduction and Targeted Therapy (2024)