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  1. Article

    Open Access

    Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

    Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no approved RSV-specific therapeutic small molecules available. Using ...

    Qi Yang, Bao Xue, Fengjiang Liu, Yongzhi Lu… in Signal Transduction and Targeted Therapy (2024)

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  2. No Access

    Article

    Identification and synthesis of low-molecular weight cholecystokinin B receptor (CCKBR) agonists as mediators of long-term synaptic potentiation

    Recently, He et al. reported that CCKB receptors located in the neocortex of the brain when bound to their bound natural ligand, CCK peptides, enhance memory, bringing up the possibility that agonists targetin...

    Yanmei Zhang, Yican Wang, Yi** Guo, **xi Liao… in Medicinal Chemistry Research (2019)

  3. No Access

    Article

    Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets

    More than two decades of research has revealed a combination of proteases that determine cartilage degradation in osteoarthritis. These include metalloproteinases, which degrade the major macromolecules in car...

    Rachel E. Miller, Yongzhi Lu, Micky D. Tortorella… in Current Rheumatology Reports (2013)

  4. No Access

    Article

    Fluorescence Studies on a Designed Peptide of REIP as a Potential Hydrophobic Drug Carrier

    Many hydrophobic drugs have limited or no activity in clinical application due to their poor aqueous solubility. In order to find fine delivery system, we designed a novel peptide REIP (Ac-RIEIRIEIAPAIEIRIEIR)...

    Yongzhi Lu, **aojun Zhao in International Journal of Peptide Research and Therapeutics (2011)