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Article
Organic heterojunction synaptic device with ultra high recognition rate for neuromorphic computing
Traditional computing structures are blocked by the von Neumann bottleneck, and neuromorphic computing devices inspired by the human brain which integrate storage and computation have received more and more at...
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Article
Open AccessHigh-performance ferroelectric field-effect transistors with ultra-thin indium tin oxide channels for flexible and transparent electronics
With the development of wearable devices and hafnium-based ferroelectrics (FE), there is an increasing demand for high-performance flexible ferroelectric memories. However, develo** ferroelectric memories th...
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Article
TIMEAS, a promising method for the stratification of testicular germ cell tumor patients with distinct immune microenvironment, clinical outcome and sensitivity to frontline therapies
With the heterogeneous genetic background, prognosis prediction and therapeutic targets for testicular germ cell tumors (TGCTs) are still unclear. We defined the tumor immune microenvironment activation status...
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Article
Open AccessReconfigurable neuromorphic memristor network for ultralow-power smart textile electronics
Neuromorphic computing memristors are attractive to construct low-power- consumption electronic textiles due to the intrinsic interwoven architecture and promising applications in wearable electronics. Develop...
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Article
Open AccessTargeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling
Although androgen receptor (AR) can influence bladder cancer (BCa) initiation and progression, its impact on tumor immune escape remains unclear. Here, we found that targeting AR could enhance natural killer (...
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Article
Open AccessRisk subty** and prognostic assessment of prostate cancer based on consensus genes
Prostate cancer (PCa) is the most frequent malignancy in male urogenital system around worldwide. We performed molecular subty** and prognostic assessment based on consensus genes in patients with PCa. Five ...
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Article
A high-speed 2D optoelectronic in-memory computing device with 6-bit storage and pattern recognition capabilities
The explosively developed era of big-data compels the increasing demand of nonvolatile memory with high efficiency and excellent storage properties. Herein, we fabricated a high-speed photoelectric multilevel ...
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Chapter
Emerging Devices for Sensing-Memory-Computing Applications
Traditional artificial visual system consisting of separated photodetector, memory unit, and processing unit is facing the problems of high energy consumption and high delay, not conducive to the development o...
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Article
Open AccessTargeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression
Long non-coding RNAs (lncRNAs) have been found to play critical roles in regulating gene expression, but their function in translational control is poorly understood. We found lnc-OPHN1-5, which lies close to ...
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Article
Open AccessIntegrative analysis the characterization of peroxiredoxins in pan-cancer
Peroxiredoxins (PRDXs) are an antioxidant enzymes protein family involved in several biological functions such as differentiation, cell growth. In addition, previous studies report that PRDXs play critical rol...
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Article
Open AccessAndrogen receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR
While the androgen receptor (AR) may influence the progression of clear cell renal cell carcinoma (ccRCC), its role to impact vasculogenic mimicry (VM) to alter the ccRCC progression and metastasis remains obs...
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Article
Open AccessThe MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer
The antiandrogen enzalutamide (Enz) has improved survival in castration resistant prostate cancer (CRPC) patients. However, most patients eventually develop Enz resistance that may involve inducing the androge...
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Article
Open AccessEpigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivation, and favourable prognosis
Ageing-associated molecular changes have been assumed to trigger malignant transformations and the epigenetic clock, and the DNA methylation age has been shown to be highly correlated with chronological age. H...
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Article
Open AccessDo polymorphisms in protein kinase catalytic subunit alpha-1 gene associated with cancer susceptibility? a meta-analysis and systematic review
Currently, several studies have demonstrated that PRKAA1 polymorphisms conduce to the development of cancer. PRKAA1 gene encodes the AMP-activated protein kinase summit-α1, and plays an important role in cell met...
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Article
Analysis of the Coupling Effects of TiB Whiskers and TiC Particles on the Fracture Toughness of (TiB + TiC)/TC4 Composites: Experiment and Modeling
(TiB + TiC)/TC4 composites reinforced with different amounts of TiB whiskers and TiC particles are produced by common casting and hot forging technology. Then the fracture toughness of (TiB + TiC)/TC4 composit...
