33 Result(s)
within
Jia-Wen **e
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessAstrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice
Epigenetic mechanisms bridge genetic and environmental factors that contribute to the pathogenesis of major depression disorder (MDD). However, the cellular specificity and sensitivity of environmental stress ...
-
Article
Open AccessExpression quantitative trait methylation analysis elucidates gene regulatory effects of DNA methylation: the Framingham Heart Study
Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs ...
-
Article
Open AccessThe normal impact stiffness of a debris-flow flexible barrier
This paper proposes a normal oriented impact stiffness of a three-supporting cable flexible barrier under a small pretension stress to estimate the structural load behaviour, and employs two categories of smal...
-
Article
Open AccessWhole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program
Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare bl...
-
Article
Open AccessIntestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost
Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2 doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 receptor gene is expressed and wher...
-
Article
Open AccessApplication of nanoindentation technology in testing the mechanical properties of skull materials
Three-point bending test, compression test and tensile test can detect the mechanical properties of the whole layer of skull, but cannot detect the mechanical properties of the inner plate, the diploe and the ...
-
Article
Open AccessTrajectory of immune evasion and cancer progression in hepatocellular carcinoma
Immune evasion is key to cancer initiation and later at metastasis, but its dynamics at intermediate stages, where potential therapeutic interventions could be applied, is undefined. Here we show, using multi-...
-
Article
Open AccessAuthor Correction: Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
-
Article
Open AccessNovel capsid binder and PI4KIIIbeta inhibitors for EV-A71 replication inhibition
The Hand, Foot and Mouth Disease (HFMD) is a highly contagious viral illness generally manifests as a mild disease in young children and immunocompromised adults. It has however emerged as a significant public...
-
Article
Open AccessTranscriptome divergence between developmental senescence and premature senescence in Nicotiana tabacum L.
Senescence is a degenerative process triggered by intricate and coordinated regulatory networks, and the mechanisms of age-dependent senescence and stress-induced premature senescence still remain largely elus...
-
Article
Cell-type-specific 3D epigenomes in the develo** human cortex
Lineage-specific epigenomic changes during human corticogenesis have been difficult to study owing to challenges with sample availability and tissue heterogeneity. For example, previous studies using single-ce...
-
Article
Open AccessDearomative 1,4-difunctionalization of naphthalenes via palladium-catalyzed tandem Heck/Suzuki coupling reaction
Dearomative functionalization reactions represent an important strategy for the synthesis of valuable three-dimensional molecules from simple planar aromatics. Naphthalene is a challenging arene towards transi...
-
Article
Open AccessArm-pull thrust in human swimming and the effect of post-activation potentiation
The aim of this study was to analyse the front-crawl arm-pull kinetics and kinematics, comparing it before and after post-activation potentiation (PAP), and the associations between variables describing of the...
-
Article
Open AccessIncreased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
Despite considerable progress in schizophrenia genetics, most findings have been for large rare structural variants and common variants in well-imputed regions with few genes implicated from exome sequencing. ...
-
Article
Open AccessFemale bias in an immigratory population of Cnaphalocrocis medinalis moths based on field surveys and laboratory tests
Sex ratio bias is common in migratory animals and can affect population structure and reproductive strategies, thereby altering population development. However, little is known about the underlying mechanisms ...
-
Article
Open AccessTemporal and Spatial Evolution of Vegetation Coverage in the Mianyuan River Basin Influenced by Strong Earthquake Disturbance
The 2008 Wenchuan earthquake caused significant economic losses and degradation of regional ecosystems, including the terrestrial vegetation. Since the vegetation root system can enhance the soil’s anti-erosio...
-
Article
Open AccessMulti-platform discovery of haplotype-resolved structural variation in human genomes
The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies of human genetic diversity and disease association. Here, we apply a suite of long-read, short-read, ...
-
Article
Open AccessAssociation between urinary sodium excretion and uric acid, and its interaction on the risk of prehypertension among Chinese young adults
High uric acid (UA) level and high salt intake are reportedly associated with cardiovascular disease. This study investigated the association between UA and urinary sodium excretion, as well as its interaction...
-
Article
Open AccessRivaroxaban does not influence hemorrhagic transformation in a diabetes ischemic stroke and endovascular thrombectomy model
Managing endovascular thrombectomy (ET) in diabetic ischemic stroke (IS) with novel anticoagulants is challenging due to putative risk of intracerebral hemorrhage. The study evaluates increased hemorrhagic tra...
-
Article
Open AccessEffect of Salt Intake on Plasma and Urinary Uric Acid Levels in Chinese Adults: An Interventional Trial
Uric acid (UA) has been proposed as an important risk factor for cardiovascular and renal morbidity. We conducted an interventional trial to assess effects of altered salt intake on plasma and urine UA levels ...
