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Article
Applying Latent Variable Models to Estimate Cumulative Exposure Burden to Chemical Mixtures and Identify Latent Exposure Subgroups: A Critical Review and Future Directions
Environmental mixtures, which reflect joint exposure to multiple environmental agents, are a major focus of environmental health and risk assessment research. Advancements in latent variable modeling and psych...
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Article
Open AccessVitamin D and Toxic Metals in Pregnancy - a Biological Perspective
To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women.
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Article
Open AccessEarly life exposure to secondhand tobacco smoke and eating behaviors at age 12 years
Prenatal or early childhood secondhand tobacco smoke (SHS) exposure increases obesity risk. However, the potential mechanisms underlying this association are unclear, but obesogenic eating behaviors are one pa...
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Article
Phthalate mixtures and insulin resistance: an item response theory approach to quantify exposure burden to phthalate mixtures
Molar sums are often used to quantify total phthalate exposure, but they do not capture patterns of exposure to multiple phthalates.
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Article
Estimating Causal Effects of Interventions on Early-life Environmental Exposures Using Observational Data
We discuss how epidemiologic studies have used observational data to estimate the effects of potential interventions on early-life environmental exposures. We summarize the value of posing questions about inte...
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Article
SPR Perspectives: scientific opportunities in the Environmental influences on Child Health Outcomes Program
Drawing upon extant data from existing pediatric cohorts and new follow-up of a diverse set of pediatric cohorts from across the United States, the Environmental influences on Child Health Outcomes (ECHO) Prog...
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Article
In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals
Low-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps ...
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Article
Gestational perfluoroalkyl substance exposure and body mass index trajectories over the first 12 years of life
Gestational exposure to perfluoroalkyl substances (PFAS), a ubiquitous class of persistent endocrine disrupting chemicals, is associated with increased risk of obesity and cardiometabolic disease. However, it ...
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Article
Open AccessPredictors and reproducibility of urinary organophosphate ester metabolite concentrations during pregnancy and associations with birth outcomes in an urban population
Organophosphate esters (OPEs) are synthetic chemicals used as flame retardants and plasticizers in a variety of goods. Despite ubiquitous human exposures and laboratory evidence that prenatal OPE exposures may...
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Article
Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program
The Environmental Influences on Child Health Outcomes (ECHO) Program will evaluate environmental factors affecting children’s health (perinatal, neurodevelopmental, obesity, respiratory, and positive health ou...
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Article
Statistical Approaches for Investigating Periods of Susceptibility in Children’s Environmental Health Research
Children’s environmental health researchers are increasingly interested in identifying time intervals during which individuals are most susceptible to adverse impacts of environmental exposures. We review rece...
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Article
Environmental Exposure Mixtures: Questions and Methods to Address Them
This review provides a summary of statistical approaches that researchers can use to study environmental exposure mixtures. Two primary considerations are the form of the research question and the statistical ...
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Article
Open AccessMaternal urinary phthalates and sex-specific placental mRNA levels in an urban birth cohort
Prenatal urinary concentrations of phthalates in women participants in an urban birth cohort were associated with outcomes in their children related to neurodevelopment, autoimmune disease risk, and fat mass a...
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Article
Lipid and Creatinine Adjustment to Evaluate Health Effects of Environmental Exposures
Urine- and serum-based biomarkers are useful for assessing individuals’ exposure to environmental factors. However, variations in urinary creatinine (a measure of dilution) or serum lipid levels, if not adequa...
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Article
Consumer product exposures associated with urinary phthalate levels in pregnant women
Human phthalate exposure is ubiquitous, but little is known regarding predictors of urinary phthalate levels. To explore this, 50 pregnant women aged 18–38 years completed two questionnaires on potential phtha...
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Article
Open AccessSeasonal modification of the association between temperature and adult emergency department visits for asthma: a case-crossover study
The objective of this study is to characterize the effect of temperature on emergency department visits for asthma and modification of this association by season. This association is of interest in its own rig...
