-
Article
Open AccessMultimodal cell atlas of the ageing human skeletal muscle
Muscle atrophy and functional decline (sarcopenia) are common manifestations of frailty and are critical contributors to morbidity and mortality in older people1. Deciphering the molecular mechanisms underlying s...
-
Article
Open AccessAuthor Correction: Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
-
Article
Open AccessSenescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
Tissue regeneration requires coordination between resident stem cells and local niche cells1,2. Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress...
-
Article
Open AccessSestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
A unique property of skeletal muscle is its ability to adapt its mass to changes in activity. Inactivity, as in disuse or aging, causes atrophy, the loss of muscle mass and strength, leading to physical incapa...
-
Article
Open AccessChromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation
Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although or...
