9 Result(s)
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Abul B. M. M. K. Islam
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Article
Association of transcription factor 7-like 2 rs12255372 polymorphism with susceptibility of type 2 diabetes mellitus in Bangladeshi population
Polymorphism of transcription factor 7-like 2 (TCF7L2) has a link with type 2 diabetes mellitus (T2DM) through β cell dysfunction that causes defect in blood glucose homeostasis. This case–control study recruited...
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Article
Open AccessSingle-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer
Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, the duration of clin...
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Article
Open AccessAncestral function of Inhibitors-of-kappaB regulates Caenorhabditis elegans development
Mammalian IκB proteins (IκBs) exert their main function as negative regulators of NF-κB, a central signaling pathway controlling immunity and inflammation. An alternative chromatin role for IκBs has been shown...
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Open AccessSingle cell RNA-sequencing identifies a metabolic aspect of apoptosis in Rbf mutant
The function of Retinoblastoma tumor suppressor (pRB) is greatly influenced by the cellular context, therefore the consequences of pRB inactivation are cell-type-specific. Here we employ single cell RNA-sequen...
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Open AccessChromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation
Extracellular stimuli induce gene expression responses through intracellular signaling mediators. The p38 signaling pathway is a paradigm of the mitogen-activated protein kinase (MAPK) family that, although or...
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Open AccessConserved antigenic sites between MERS-CoV and Bat-coronavirus are revealed through sequence analysis
MERS-CoV is a newly emerged human coronavirus reported closely related with HKU4 and HKU5 Bat coronaviruses. Bat and MERS corona-viruses are structurally related. Therefore, it is of interest to estimate the d...
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Open AccessCorrection: Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium
Nature Communications 6: Article number: 8510 (2015); Published: 14 October 2015; Updated: 4 March 2016 The original version of this Article contained a typographical error in the spelling of the author Zhenyi...
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Open AccessDNA methylation and hormone receptor status in breast cancer
We examined whether differences in tumor DNA methylation were associated with more aggressive hormone receptor-negative breast cancer in an ethnically diverse group of patients in the Breast Cancer Care in Chi...
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Open AccessNotch signal strength controls cell fate in the haemogenic endothelium
Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta–gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on...
