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Article
Open AccessEffects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study
Mental health conditions represent one of the major groups of non-transmissible diseases. Physical activity (PA) and sedentary time (ST) have been shown to affect mental health outcomes in opposite directions....
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Article
Open AccessThe genetics of falling susceptibility and identification of causal risk factors
Falls represent a huge health and economic burden. Whilst many factors are associated with fall risk (e.g. obesity and physical inactivity) there is limited evidence for the causal role of these risk factors. ...
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Article
Open AccessBody mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study
Major depressive disorder (MDD) has a significant impact on global burden of disease. Complications in clinical management can occur when response to pharmacological modalities is considered inadequate and sym...
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Article
Open AccessBMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study
Previous studies have linked higher body mass index (BMI) to lower subjective well-being in adult European ancestry populations. However, our understanding of these relationships across different populations i...
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Article
Open AccessMendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality
Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is lim...
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Article
Open AccessUsing Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health
Late diurnal preference has been linked to poorer mental health outcomes, but the understanding of the causal role of diurnal preference on mental health and wellbeing is currently limited. Late diurnal prefer...
