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Article
Open AccessGenetic associations of risk behaviours and educational achievement
Risk behaviours are common in adolescent and persist into adulthood, people who engage in more risk behaviours are more likely to have lower educational attainment. We applied genetic causal inference methods ...
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Article
Open AccessBMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study
Previous studies have linked higher body mass index (BMI) to lower subjective well-being in adult European ancestry populations. However, our understanding of these relationships across different populations i...
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Article
Open AccessMendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality
Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is lim...
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Article
Open AccessSocial mobility across the lifecourse and DNA methylation age acceleration in adults in the UK
Disadvantaged socio-economic position (SEP) is associated with greater biological age, relative to chronological age, measured by DNA methylation (positive ‘age acceleration’, AA). Social mobility has been pro...
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Article
Open AccessSocioeconomic position and adverse childhood experiences as risk factors for health-related behaviour change and employment adversity during the COVID-19 pandemic: insights from a prospective cohort study in the UK
Non-pharmaceutical interventions to reduce the spread of COVID-19 may have disproportionately affected already disadvantaged populations.
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Article
Open AccessWithin-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives ...
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Article
Open AccessOccupational physical activity, mortality and CHD events in the Italian Longitudinal Study
Several recent studies have suggested a ‘physical activity paradox’ whereby leisure-time physical activity benefits health, but occupational physical activity is harmful. However, other studies imply that occu...
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Article
Open AccessCommon health conditions in childhood and adolescence, school absence, and educational attainment: Mendelian randomization study
Good health is positively related to children’s educational outcomes, but relationships may not be causal. Demonstrating a causal influence would strongly support childhood and adolescent health as important f...
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Article
Open AccessAvoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses
Estimates from Mendelian randomization studies of unrelated individuals can be biased due to uncontrolled confounding from familial effects. Here we describe methods for within-family Mendelian randomization a...
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Article
Open AccessSystematic underestimation of the epigenetic clock and age acceleration in older subjects
The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate “age acceleration” in various tissues...
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Article
Understanding cross-cultural adoption of a first aid app
The increased availability of Wi-Fi and Internet coverage, coupled with the widespread use of Smartphones and tablet computers has facilitated the quick and efficient transfer of information through digital me...
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Book Review
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Higher education institutions and work-based learning in the UK: employer engagement within a tripartite relationship
Higher education institutions (HEIs) in the UK are increasingly engaging in work-based learning. The tripartite relationship between the HEI, the employer and the employee is viewed to be of great significanc...
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Book Review
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Student finance, information and decision making
Since the recent changes in the system of student finance in England, studies focusing on the impact of increased debt and the effect of the bursary system have concluded that the chances of achieving stated p...
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Article
Chromatin 'programming' by sequence - is there more to the nucleosome code than %GC?
The role of genomic sequence in directing the packaging of eukaryotic genomes into chromatin has been the subject of considerable recent debate. A new paper from Tillo and Hughes shows that the intrinsic therm...
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Article
Participation, financial support and the marginal student
This paper examines differences between the decision-making of marginal and nonmarginal students about participation in higher education (HE). We distinguish between two kinds of marginality: being ‘borderline...
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When home base is not a place: parents’ use of mobile telephones
More attention is being paid to the development of information and communication technologies (ICTs) that are sensitive to the needs of people in their homes. By studying mobile telephony in such settings, we ...
