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Article
Open AccessPrednisolone and rapamycin reduce the plasma cell gene signature and may improve AAV gene therapy in cynomolgus macaques
Adeno-associated virus (AAV) vector gene therapy is a promising approach to treat rare genetic diseases; however, an ongoing challenge is how to best modulate host immunity to improve transduction efficiency a...
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Article
Stabilization of HAC1 Influenza Vaccine by Spray Drying: Formulation Development and Process Scale-Up
Stable vaccines with long shelf lives and reduced dependency on the cold chain are ideal for stockpiling and rapid deployment during public emergencies, including pandemics. Spray drying is a low-cost process ...
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Hairy Roots as a Vaccine Production and Delivery System
Prevention of infectious diseases by vaccination is often limited because of the lack of safe, effective, and accessible vaccines. Traditional vaccines are expensive and require special conditions for storage,...
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Article
Open AccessPlant-produced transmission blocking Plasmodium falciparum Pfs25 subunit and VLP based vaccine candidates