17 Result(s)
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Jennifer M Anderson
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Article
Open AccessImpact of insecticide-treated bednets and indoor residual spraying in controlling populations of Phlebotomus duboscqi, the vector of Leishmania major in Central Mali
Cutaneous leishmaniasis (CL) is an endemic neglected tropical disease prevalent in several areas where seasonal malaria transmission is active. We assessed the effect of indoor residual spraying (IRS) and the ...
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Article
Open AccessHost age and Plasmodium falciparum multiclonality are associated with gametocyte prevalence: a 1-year prospective cohort study
Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle. Thus, a better understanding of which individu...
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Article
Open AccessMining a differential sialotranscriptome of Rhipicephalus microplus guides antigen discovery to formulate a vaccine that reduces tick infestations
Ticks cause massive damage to livestock and vaccines are one sustainable substitute for the acaricides currently heavily used to control infestations. To guide antigen discovery for a vaccine that targets the ...
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Article
Open AccessFleas and trypanosomes of peridomestic small mammals in sub-Saharan Mali
Fleas are obligate blood-feeding ectoparasites and vectors of several bacterial zoonotic pathogens as well as trypanosomes that parasitize rodents and other small mammals. During investigations of tick- and ro...
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Article
Open AccessCow-baited tents are highly effective in sampling diverse Anopheles malaria vectors in Cambodia
The accurate monitoring and evaluation of malaria vectors requires efficient sampling. The objective of this study was to compare methods for sampling outdoor-biting Anopheles mosquitoes in Cambodia.
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Article
Open AccessCorrection: Corrigendum: Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa
Nature Communications 6: Article number: 8614 (2015); Published: 20 October 2015; Updated: 8 January 2016. In the first paragraph of the Results section in this Article, the An. gambiae G3 line is incorrectly ...
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Article
Open AccessArtemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa
Artemisinin-resistant Plasmodium falciparum parasites are rapidly spreading in Southeast Asia, yet nothing is known about their transmission. This knowledge gap and the possibility that these parasites will sprea...
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Article
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Dominic Kwiatkowski and colleagues report analysis of genetic variation in 826 Plasmodium falciparum samples collected from 10 locations in West Africa and southeast Asia. They characterize the population structu...
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Article
Open AccessA further insight into the sialome of the tropical bont tick, Amblyomma variegatum
Ticks--vectors of medical and veterinary importance--are themselves also significant pests. Tick salivary proteins are the result of adaptation to blood feeding and contain inhibitors of blood clotting, platel...
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Article
Open AccessAn insight into the sialotranscriptome of the brown dog tick, Rhipicephalus sanguineus
Rhipicephalus sanguineus, known as the brown dog tick, is a common ectoparasite of domestic dogs and can be found worldwide. R. sanguineus is recognized as the primary vector of the etiological agent of canine mo...
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Article
Open AccessThe expression of genes coding for distinct types of glycine-rich proteins varies according to the biology of three metastriate ticks, Rhipicephalus (Boophilus) microplus, Rhipicephalus sanguineus and Amblyomma cajennense
Ticks secrete a cement cone composed of many salivary proteins, some of which are rich in the amino acid glycine in order to attach to their hosts' skin. Glycine-rich proteins (GRPs) are a large family of hete...
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Article
Open AccessExploring the mialome of ticks: an annotated catalogue of midgut transcripts from the hard tick, Dermacentor variabilis (Acari: Ixodidae)
Ticks are obligate blood feeders. The midgut is the first major region of the body where blood and microbes ingested with the blood meal come in contact with the tick's internal tissues. Little is known about ...
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Article
Open AccessInsight into the sialome of the castor bean tick, Ixodes ricinus
In recent years, there have been several sialome projects revealing transcripts expressed in the salivary glands of ticks, which are important vectors of several human diseases. Here, we focused on the sialome...
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Article
Open AccessExploring the midgut transcriptome of Phlebotomus papatasi: comparative analysis of expression profiles of sugar-fed, blood-fed and Leishmania major-infected sandflies
In sandflies, the blood meal is responsible for the induction of several physiologic processes that culminate in egg development and maturation. During blood feeding, infected sandflies are also able to transm...
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Article
Open AccessHigh degree of conservancy among secreted salivary gland proteins from two geographically distant Phlebotomus duboscqi sandflies populations (Mali and Kenya)
Salivary proteins from sandflies are potential targets for exploitation as vaccines to control Leishmania infection; in this work we tested the hypothesis that salivary proteins from geographically distant Phlebo...
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Article
Open AccessComparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis
Immune responses to sandfly saliva have been shown to protect animals against Leishmania infection. Yet very little is known about the molecular characteristics of salivary proteins from different sandflies, part...
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Chapter and Conference Paper
An overview of a compiler for scalable parallel machines
This paper presents an overview of a parallelizing compiler to automatically generate efficient code for large-scale parallel architectures from sequential input programs. This research focuses on loop-level p...
