6 Result(s)
within
Jean-François Lefebvre
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Article
Open AccessModeling gene-environment interactions in longitudinal family studies: a comparison of methods and their application to the association between the IGF pathway and childhood obesity
The interactive effect of the IGF pathway genes with the environment may contribute to childhood obesity. Such gene-environment interactions can take on complex forms. Detecting those relationships using longi...
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Article
Open AccessGENLIB: an R package for the analysis of genealogical data
Founder populations have an important role in the study of genetic diseases. Access to detailed genealogical records is often one of their advantages. These genealogical data provide unique information for res...
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Article
Open AccessHaplotype allelic classes for detecting ongoing positive selection
Natural selection eliminates detrimental and favors advantageous phenotypes. This process leaves characteristic signatures in underlying genomic segments that can be recognized through deviations in allelic or...
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Article
Tracing genetic history of modern humans using X-chromosome lineages
Genetic variability of the compound interrupted microsatellite DXS1238, in intron 44 of the dystrophin gene, provides evidence for a complex structure of the ancestral population that led to the emergence of m...
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Article
Anatomy of a founder effect: myotonic dystrophy in Northeastern Quebec
Founder effects are largely responsible for changes in frequency profiles of genetic variants in local populations or isolates. They are often recognized by elevated incidence of certain hereditary disorders a...
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Chapter and Conference Paper
The Distribution of Inversion Lengths in Bacteria
The distribution of the lengths of genomic segments inverted during the evolutionary divergence of two species cannot be inferred directly from the output of genome rearrangement algorithms, due to the rapid l...
