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  1. Article

    Open Access

    Machine learning-based somatic variant calling in cell-free DNA of metastatic breast cancer patients using large NGS panels

    Next generation sequencing of cell-free DNA (cfDNA) is a promising method for treatment monitoring and therapy selection in metastatic breast cancer (MBC). However, distinguishing tumor-specific variants from ...

    Elisabeth M. Jongbloed, Maurice P. H. M. Jansen, Vanja de Weerd… in Scientific Reports (2023)

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  2. Article

    Open Access

    Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer

    Extracellular vesicles (EVs) are actively secreted by cells into body fluids and contain nucleic acids of the cells they originate from. The goal of this study was to detect circulating tumor-derived EVs (ctEV...

    Silvia R. Vitale, Jean A. Helmijr, Marjolein Gerritsen, Hicret Coban… in BMC Cancer (2021)

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  3. No Access

    Article

    IGF1R signaling drives antiestrogen resistance through PAK2/PIX activation in luminal breast cancer

    Antiestrogen resistance in estrogen receptor positive (ER+) breast cancer is associated with increased expression and activity of insulin-like growth factor 1 receptor (IGF1R). Here, a kinome siRNA screen has ide...

    Yinghui Zhang, Lynn Wester, Jichao He, Tamar Geiger, Marja Moerkens… in Oncogene (2018)