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Article
Open AccessThe epidemiology of benzodiazepine-related toxicity in Ontario, Canada: a population-based descriptive study
Despite the widespread use of prescription benzodiazepines, there are few studies examining trends and patterns of benzodiazepine-related toxicity. We describe the epidemiology of benzodiazepine-related toxici...
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Article
Social Work Practice During COVID-19: Client Needs and Boundary Challenges
While information and communication technologies (ICTs) permeated social work practice long before the onset of COVID-19, the abrupt need to close non-essential workplaces resulted in an unparalleled incorpora...
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Article
#socialwork: Informal Use of Information and Communication Technology in Social Work
Information and communication technologies (ICTs) have transformed social realms and professional fields of practice including social work. Research is lacking on informal ICT use and its impact on clinical so...
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Article
Open AccessPreclinical studies on the toxicology, pharmacokinetics and safety of K1-70TM a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity
The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies.
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Article
Open AccessStructure and activation of the TSH receptor transmembrane domain
The thyroid-stimulating hormone receptor (TSHR) is the target autoantigen for TSHR-stimulating autoantibodies in Graves’ disease. The TSHR is composed of: a leucine-rich repeat domain (LRD), a hinge region or ...
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Article
Blocking type TSH receptor antibodies
TSH receptor (TSHR) autoantibodies (TRAbs) play a key role in the pathogenesis of Graves’ disease. In the majority of patients, TRAbs stimulate thyroid hormone synthesis via activation of the TSHR (stimulating...
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Article
In vivo effects of a human thyroid-stimulating monoclonal autoantibody (M22) and a human thyroid-blocking autoantibody (K1-70)
To study in vivo effects of the human monoclonal TSH receptor (TSHR) autoantibodies M22 (stimulating type) and K1-70 (blocking type) on thyroid hormone levels in rats.
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Article
The myelin proteins of the shark brain are similar to the myelin proteins of the mammalian peripheral nervous system
The two major structural proteins in the shark CNS are similar to the structural proteins, Po and myelin basic protein (MBP), found in the mammalian peripheral nervous system (PNS). Shark Po is 46% similar to its...
