-
Article
Association between post-treatment circulating biomarkers of inflammation and survival among stage II–III colorectal cancer patients
Biomarker studies on colorectal cancer (CRC) prognosis are limited to pre-diagnostic or pre-operative measures. Post-treatment biomarkers are not well understood for their associations with CRC survival.
-
Article
Copy number alterations are associated with metastatic-lethal progression in prostate cancer
Aside from Gleason score few factors accurately identify the subset of prostate cancer (PCa) patients at high risk for metastatic progression. We hypothesized that copy number alterations (CNAs), assessed usin...
-
Article
Open AccessInteractive decision support for esophageal adenocarcinoma screening and surveillance
A key barrier to controlling esophageal adenocarcinoma (EAC) is identifying those most likely to benefit from screening and surveillance. We aimed to develop an online educational tool, termed IC-RISC™, for pr...
-
Article
Open AccessWhole-genome sequencing of esophageal adenocarcinoma in Chinese patients reveals distinct mutational signatures and genomic alterations
While the incidence of esophageal adenocarcinoma (EAC) has risen drastically in Western countries over the last 40 years, a similar trend has not been observed for EAC in China. Here, we analyzed mutational sp...
-
Article
Open AccessMendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer
Substantial evidence supports an association between use of menopausal hormone therapy and decreased colorectal cancer (CRC) risk, indicating a role of exogenous sex hormones in CRC development. However, findi...
-
Article
Acceptability of and Adherence to an Antiretroviral-Based Vaginal Microbicide among Pregnant Women in the United States
The MTN-008 trial was the first multi-dose study conducted to evaluate the safety of a microbicide gel (2:1 randomized to tenofovir 1% or hydroxycellulose (HEC) placebo gel) during pregnancy. The study aim was...
-
Article
Open AccessCopy number alterations detected by whole-exome and whole-genome sequencing of esophageal adenocarcinoma
Esophageal adenocarcinoma (EA) is among the leading causes of cancer mortality, especially in developed countries. A high level of somatic copy number alterations (CNAs) accumulates over the decades in the pro...
-
Article
Factors associated with bone mineral density in healthy African women
There is a paucity of normative bone mineral density (BMD) data in healthy African women. Baseline total hip and lumbar spine BMD was measured in premenopausal women. BMD distribution was comparable to that of...
-
Article
Open AccessErratum To: Genetic variants in the MRPS30region and postmenopausal breast cancer risk
-
Article
Open AccessGenetic variants in the MRPS30 region and postmenopausal breast cancer risk
Genome-wide association studies have identified several genomic regions that are associated with breast cancer risk, but these provide an explanation for only a small fraction of familial breast cancer aggrega...
-
Article
Open AccessComparison of amplification enzymes for Hepatitis C Virus quasispecies analysis
Hepatitis C virus (HCV) circulates as quasispecies (QS), whose evolution is associated with pathogenesis. Previous studies have suggested that the use of thermostable polymerases without proofreading function ...
