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Open AccessMCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells
Current treatment for patients with metastatic melanoma include molecular-targeted therapies and immune checkpoint inhibitors. However, a subset of melanomas are difficult-to-treat. These melanomas include tho...
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Open AccessEfficient identification of mutations that potentially confer treatment resistance through computational derivation
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Article
Endocrine Disrupting Activities of the Flavonoid Nutraceuticals Luteolin and Quercetin
Dietary plant flavonoids have been proposed to contribute to cancer prevention, neuroprotection, and cardiovascular health through their anti-oxidant, anti-inflammatory, pro-apoptotic, and antiproliferative ac...
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Chapter
Inflammation as a Target in Prostate Cancer
Epidemiological studies have implicated chronic infections and inflammation as major risk factors for a variety of human cancers. Emerging evidence suggests that chronic inflammation is important for the devel...
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Article
Growth factors in benign prostatic hyperplasia: Basic science implications
Benign prostatic hyperplasia (BPH) is the most common proliferative disease of the prostate of men in the United States. The histopathology of BPH strongly implicates local paracrine and autocrine growth facto...
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Protocol
Analysis of Steroid Hormone-Induced Histone Acetylation by Chromatin Immunoprecipitation Assay
Steroid hormone receptors are members of the nuclear receptor family of ligand-activated transcriptional regulatory proteins. Recent work in the field of nuclear receptor action has demonstrated an association...
