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Article
Open AccessDistinct tumor microenvironments of lytic and blastic bone metastases in prostate cancer patients
The most common metastatic lesions of prostate cancer are in bone and can be classified into three distinct pathology subtypes: lytic, blastic, and an indeterminate mixture of both. We investigated a cohort of...
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Article
Prostatic adenocarcinoma CNS parenchymal and dural metastases: alterations in ERG, CHD1 and MAP3K7 expression
Prostatic carcinoma metastatic to dura is commonly encountered at autopsy, but presenting as a dural or, especially parenchymal, brain metastasis during life is far less common. Our group has been interested i...
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Requisite for Collection and Distribution of Tissue and Fluid Specimens for Molecular Diagnostics and Discovery in Bladder Cancer
The trend of medical treatment becoming more and more personalized has also impacted the management of patients at risk, diagnosed and treated for bladder cancer. Traditional pathological specimens obtained th...
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Article
Detection and grading of prostate cancer using temporal enhanced ultrasound: combining deep neural networks and tissue mimicking simulations
Temporal Enhanced Ultrasound (TeUS) has been proposed as a new paradigm for tissue characterization based on a sequence of ultrasound radio frequency (RF) data. We previously used TeUS to successfully address ...
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Article
Open AccessClear cell urothelial carcinoma of the urinary bladder: a case report and review of the literature
The occurrence of clear cell tumors in the bladder is not uncommon. Clear cell dysplasia is well-described and characterized by focal replacement of transitional mucosa by cells with abundant clear cytoplasm, ...
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Article
Open AccessThe MAPP research network: a novel study of urologic chronic pelvic pain syndromes
Urologic chronic pelvic pain syndrome (UCPPS) may be defined to include interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The hallmark symptom...
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Article
Open AccessThe MAPP research network: design, patient characterization and operations
The “Multidisciplinary Approach to the Study of Chronic Pelvic Pain” (MAPP) Research Network was established by the NIDDK to better understand the pathophysiology of urologic chronic pelvic pain syndromes (UCP...
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Article
Open AccessRenal epithelioid angiomyolipoma with a negative premelanosome marker immunoprofile: a case report and review of the literature
The rare variant of renal epithelioid/pleomorphic angiomyolipoma has been reported in approximately 120 cases. One of the most important characteristics to differentiate these tumors from other renal cell neop...
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Article
Current Perspectives on Gleason Grading of Prostate Cancer
The 5-tier Gleason grading system for prostate cancer, introduced in 1966, has been proven to be one of the main independent predictors of prostate cancer outcome. This review addresses interobserver concordan...
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Article
Open AccessCarcinoid tumor of the verumontanum (colliculus seminalis) of the prostatic urethra with a coexisting prostatic adenocarcinoma: a case report
Urethral carcinoid tumors are very rare tumors with only four cases described in the literature.
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Article
Erratum: CBP/p300-mediated acetylation of histone H3 on lysine 56
Nature 459, 113–117 (2009) In Fig. 4e of this Letter, one band was incorrectly labelled. We thank B. Lüscher for drawing this to our attention. The correctly labelled version of the figure is provided below. A...
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CBP/p300-mediated acetylation of histone H3 on lysine 56
An acetylation mark within the core domain of histone H3, on lysine 56 (H3K56ac), has an important role in chromatin assembly during DNA replication and repair in budding yeast, but it has not been studied in ...
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Article
Growth factors in benign prostatic hyperplasia: Basic science implications
Benign prostatic hyperplasia (BPH) is the most common proliferative disease of the prostate of men in the United States. The histopathology of BPH strongly implicates local paracrine and autocrine growth facto...
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Article
A case of polyomavirus-associated nephropathy presenting late after transplantation
Polyomavirus-associated nephropathy (PVAN), an important cause of allograft failure in renal transplant recipients, is usually diagnosed within 12 months of renal transplantation. Bansal et al. present a case of ...
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Article
A case of nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis
Background A 61-year-old female with end-stage renal disease who was undergoing hemodialysis presented with an 8-week history of upper and lower extremity weakness associated with skin tightness and contractures.
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Connective Tissue Growth Factor Expression in Pediatric Myofibroblastic Tumors
