The Sedated Society
The Causes and Harms of our Psychiatric Drug Epidemic
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Open AccessA pilot study to explore patterns and predictors of delayed kidney decline after cardiopulmonary bypass
There is no current consensus on the follow up of kidney function in patients undergoing cardiopulmonary bypass (CPB). The main objectives of this pilot study is to collect preliminary data on kidney function ...
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Article
Open AccessOdd Distances in Colourings of the Plane
We prove that every finite colouring of the plane contains a monochromatic pair of points at an odd distance from each other.
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Open AccessSeparating Polynomial \(\chi \) -Boundedness from \(\chi \) -Boundedness
Extending the idea from the recent paper by Carbonero, Hompe, Moore, and Spirkl, for every function $$f:\mathbb {N}\rightarrow \mathbb {N}\cup...
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Open AccessGrounded L-Graphs Are Polynomially \(\chi \) -Bounded
A grounded L-graph is the intersection graph of a collection of “L” shapes whose topmost points belong to a common horizontal line. We prove that every grounded L-graph with clique number
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Open AccessImpaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis
Regulation of cutaneous immunity is severely compromised in inflammatory skin disease. To investigate the molecular crosstalk underpinning tolerance versus inflammation in atopic dermatitis, we utilise a human...
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Vertex-Minor-Closed Classes are χ-Bounded
We prove a conjecture of Geelen that every proper vertex-minor-closed class of graphs is χ-bounded.
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Open AccessWhole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features
The value of genome-wide over targeted driver analyses for predicting clinical outcomes of cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic lymphocytic leukemia patients e...
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Article
Open AccessSmart textiles using fluid-driven artificial muscle fibers
The marriage of textiles with artificial muscles to create smart textiles is attracting great attention from the scientific community and industry. Smart textiles offer many benefits including adaptive comfort...
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Article
Revisiting comparisons of income inequality when Lorenz curves intersect
The main contribution of Davies and Hoy (Am Econ Rev 85:980–986, 1995) was a “necessary and sufficient” condition for comparing inequality between income distributions according to the principle of transfer se...
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Open AccessSmart surgical sutures using soft artificial muscles
Wound closure with surgical sutures is a critical challenge for flexible endoscopic surgeries. Substantial efforts have been introduced to develop functional and smart surgical sutures to either monitor wound ...
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Article
Open AccessClinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)
The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of hea...
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Open AccessCompetencies and training of radiographers and technologists for PET/MR imaging - a study from the UK MR-PET network
After the success of PET/CT as a clinical diagnostic tool, the introduction of PET/MRI is a natural development aimed at further improving combined diagnostic imaging and reduced ionising radiation dose for ha...
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Open AccessGenomic programming of IRF4-expressing human Langerhans cells
Langerhans cells (LC) can prime tolerogenic as well as immunogenic responses in skin, but the genomic states and transcription factors (TF) regulating these context-specific responses are unclear. Bulk and sin...
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The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and **st
The mouse X-inactivation center (**c) locus represents a powerful model for understanding the links between genome architecture and gene regulation, with the non-coding genes **st and Tsix showing opposite develo...
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Chapter
Foreword: Pathways of Affective Scholarship
This book is the result of considerable struggle, within the social sciences and beyond, to both acknowledge and determine the enabling role of affect and emotion in social science research. Drawing together a...
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Chapter
Factors Affecting Failure
At a time of global economic downturn, there is a temptation for healthcare organisations to focus on cost reduction rather than on quality improvement as a business strategy. However such a strategy can indee...
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Chapter
Political Pills: Psychopharmaceuticals and Neoliberalism as Mutually Supporting
This chapter argues that a core explanatory variable in the spread of psychopharmaceuticals has been the ability of such products since the 1980s to serve key aims of the neoliberal political economy. Thus to ...
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Introduction
The prescribing and consumption of psychiatric drugs has reached epidemic levels in contemporary society. Over the past decade, this class of medications has become one of the most prescribed across the develo...
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Open AccessBack to balance: labour therapeutics and the depoliticisation of workplace distress
This article assesses the rise in diverse workplaces of what the author terms “labour therapeutics”—the application of therapeutic ideas and interventions to the understanding and management of employee distre...
