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Article
Open AccessRapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures
Fragment based methods are now widely used to identify starting points in drug discovery and generation of tools for chemical biology. A significant challenge is optimization of these weak binding fragments to...
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Article
Open AccessThe cost of diagnostic uncertainty: a prospective economic analysis of febrile children attending an NHS emergency department
Paediatric fever is a common cause of emergency department (ED) attendance. A lack of prompt and definitive diagnostics makes it difficult to distinguish viral from potentially life-threatening bacterial cause...
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Article
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
The anti-apoptotic function of the 70 kDa family of heat shock proteins and their role in cancer is well documented. Dual targeting of Hsc70 and Hsp70 with siRNA induces proteasome-dependent degradation of Hsp...
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Chapter
Paleoecological Insights on Fixed Tree Island Development in the Florida Everglades: I. Environmental Controls
Palynological and geochemical analyses of sediment cores collected on two tree islands in the Florida Everglades indicate long-term hydrologic and chemical differences between tree islands and surrounding mars...
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Article
Crystal structure of an RNA aptamer–protein complex at 2.8 Å resolution
The crystal structure, at 2.8 Å resolution, of an RNA aptamer bound to bacteriophage MS2 coat protein has been determined. It provides an opportunity to compare the interactions of MS2 coat protein and wild ty...
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Article
Crystal structure of an RNA bacteriophage coat protein–operator complex
THE RNA bacteriophage MS2 is a convenient model system for the study of protein–RNA interactions. The MS2 coat protein achieves control of two distinct processes—sequence-specific RNA encapsidation and repress...
