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Article
Open AccessPhoton-Counting Computed Tomography (PC-CT) of the spine: impact on diagnostic confidence and radiation dose
Computed tomography (CT) is employed to evaluate surgical outcome after spinal interventions. Here, we investigate the potential of multispectral photon-counting computed tomography (PC-CT) on image quality, d...
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Article
Open AccessStimulated Raman histology for histological evaluation of oral squamous cell carcinoma
To investigate whether in patients undergoing surgery for oral squamous cell carcinoma, stimulated Raman histology (SRH), in comparison with H&E-stained frozen sections, can provide accurate diagnoses regardin...
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Article
Open AccessSpatially resolved transcriptomic profiles reveal unique defining molecular features of infiltrative 5ALA-metabolizing cells associated with glioblastoma recurrence
Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon rec...
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Article
Open AccessNeuropathological interpretation of stimulated Raman histology images of brain and spine tumors: part B
Intraoperative histopathological examinations are routinely performed to provide neurosurgeons with information about the entity of tumor tissue. Here, we quantified the neuropathological interpretability of s...
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Article
Open AccessStimulated Raman histology in the neurosurgical workflow of a major European neurosurgical center — part A
Histopathological diagnosis is the current standard for the classification of brain and spine tumors. Raman spectroscopy has been reported to allow fast and easy intraoperative tissue analysis. Here, we report...
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Article
Open AccessA carbon nanotube tape for serial-section electron microscopy of brain ultrastructure
Automated tape-collecting ultramicrotomy in conjunction with scanning electron microscopy (SEM) is a powerful approach for volume electron microscopy and three-dimensional neuronal circuit analysis. Current ta...
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Article
Axonal synapse sorting in medial entorhinal cortex
Research on neuronal connectivity in the cerebral cortex has focused on the existence and strength of synapses between neurons, and their location on the cell bodies and dendrites of postsynaptic neurons. The ...
