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Article
Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study
The determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asthma (SEA) on biological treatment (BioT) remain elusive.
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Article
Development and Application of an Active Pharmacovigilance Framework Based on Electronic Healthcare Records from Multiple Centers in Korea
With the availability of retrospective pharmacovigilance data, the common data model (CDM) has been identified as an efficient approach towards anonymized multicenter analysis; however, the establishment of a ...
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Article
Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance
Elevated levels of plasma branched-chain amino acids (BCAAs) have been associated with insulin resistance and type 2 diabetes since the 1960s. Pharmacological activation of branched-chain α-ketoacid dehydrogen...
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Article
Design and Examination of Electrified Exhaust Brake System Using Direct Current Motor
Vehicle systems for safety and driver convenience are being installed worldwide. In particular, in the case of a large vehicle accident, various safety devices are applied to avoid risks to human life and prop...
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Article
Open AccessPeripheral blood transcriptomic clusters uncovered immune phenotypes of asthma
Transcriptomic analysis has been used to elucidate the complex pathogenesis of heterogeneous disease and may also contribute to identify potential therapeutic targets by delineating the hub genes. This study a...
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Article
Open AccessCigarette smoke aggravates asthma by inducing memory-like type 3 innate lymphoid cells
Although cigarette smoking is known to exacerbate asthma, only a few clinical asthma studies have been conducted involving smokers. Here we show, by comparing paired sputum and blood samples from smoking and n...
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Article
Open AccessUltra-high-resolution computed tomography shows changes in the lungs related with airway hyperresponsiveness in a murine asthma model
In vivo presentation of airway hyper-responsiveness (AHR) at the different time points of the allergic reaction is not clearly understood. The purpose of this study was to investigate how AHR manifests in the ...
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Article
Open AccessAmino acid transporters as tetraspanin TM4SF5 binding partners
Transmembrane 4 L6 family member 5 (TM4SF5) is a tetraspanin that has four transmembrane domains and can be N-glycosylated and palmitoylated. These posttranslational modifications of TM4SF5 enable homophilic or h...
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Article
Open AccessTM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis
Reactive oxygen species (ROS) regulate cell fate, although signaling molecules that regulate ROS hormesis remain unclear. Here we show that transmembrane 4 L six family member 5 (TM4SF5) in lung epithelial cel...
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Article
Open AccessPharmacological activity and quantitative analysis of flavonoids isolated from the flowers of Begonia semperflorens Link et Otto
Begonia semperflorens Link et Otto has been broadly raised up for ornamental purpose as well comestible blossom. As the reproductive structures of phanerogams, flowers contain various secondary metabolites and ha...
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Article
Re-exposure to low osmolar iodinated contrast media in patients with prior moderate-to-severe hypersensitivity reactions: A multicentre retrospective cohort study
To evaluate the outcomes of re-exposure to low-osmolar iodinated contrast medium (LOCM) in patients with a history of moderate-to-severe hypersensitivity reaction (HSR).
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Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Article
A new pregnane hexaglycoside from Adonis multiflora
A new pregnane hexaglycoside, named amurensioside L (1), was isolated from the whole plant of Adonis multiflora. Amurensioside L (1) emerged to be new pregnane hexaglycoside which we full...
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Article
Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities
A new isoprenylated flavonoid, 2S-5,7,2′,4′-tetrahydroxy-3′,5′-di-(γ,γ-dimethylallyl)flavanone, sanggenol Q (1), along with seven known isoprenylated flavonoids, sanggenol A (2), sanggenol L (3), kuwanon T (4), c...
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Article
New hydroxy fatty acid from the root bark of Morus alba L.
A new hydroxyl fatty acid, named sangbaimoric acid (1), was isolated from the root bark of Morus alba L. The chemical structure of compound 1 was established as 2-methoxyoctadeca-3Z,5Z-dienoic acid on the basis o...
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Article
Open AccessAn Activin A/BMP2 chimera, AB215, blocks estrogen signaling via induction of ID proteins in breast cancer cells
One in eight women will be affected by breast cancer in her lifetime. Approximately 75% of breast cancers express estrogen receptor alpha (ERα) and/or progesterone receptor and these receptors are markers for ...
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Article
Versatile surface plasmon resonance of carbon-dot-supported silver nanoparticles in polymer optoelectronic devices
The coupling of surface plasmons and excitons in organic materials can improve the performance of organic optoelectronic devices. Here, we prepare carbon-dot-supported silver nanoparticles (CD–Ag nanoparticles...
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Article
Open AccessEnvironmental and occupational respiratory diseases – 1045. Skin prick tests and allergen-specific IgE tests for fungus in patients with chronic lower respiratory symptoms
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Chapter and Conference Paper
Magnetic Circuit Design for Improving Performance of In-Wheel Type IPMSM
This paper presents rib design in the rotor of IPMSM to increase maximum power in the field weakening region without variation of PM usage, conductor and size. Rib design is critical issue in the design of IPM...
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Article
Quantitative analysis of dynamic airway changes after methacholine and salbutamol inhalation on xenon-enhanced chest CT
To investigate the dynamic changes in airways in response to methacholine and salbutamol inhalation and to correlate the xenon ventilation index on xenon-enhanced chest CTs in asthmatics.
