12 Result(s)

Article

Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study

Mental health conditions represent one of the major groups of non-transmissible diseases. Physical activity (PA) and sedentary time (ST) have been shown to affect mental health outcomes in opposite directions....

Francesco Casanova, Jessica O’Loughlin, Vasilis Karageorgiou… in BMC Medicine (2023)

Article

Body mass index and inflammation in depression and treatment-resistant depression: a Mendelian randomisation study

Major depressive disorder (MDD) has a significant impact on global burden of disease. Complications in clinical management can occur when response to pharmacological modalities is considered inadequate and sym...

Vasilios Karageorgiou, Francesco Casanova, Jessica O’Loughlin, Harry Green… in BMC Medicine (2023)

Article

BMI and well-being in people of East Asian and European ancestry: a Mendelian randomisation study

Previous studies have linked higher body mass index (BMI) to lower subjective well-being in adult European ancestry populations. However, our understanding of these relationships across different populations i...

Jessica O’Loughlin, Francesco Casanova, Amanda Hughes… in Translational Psychiatry (2023)

Article

Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality

Extensive evidence links higher body mass index (BMI) to higher odds of depression in people of European ancestry. However, our understanding of the relationship across different settings and ancestries is lim...

Jessica O’Loughlin, Francesco Casanova, Zammy Fairhurst-Hunter… in BMC Medicine (2023)

Article

Correcting for selection bias in two-stage trials with multiple correlated outcomes: application to seamless phase ii/iii clinical trials

David Robertson, A Toby Prevost, Jack Bowden in Trials (2015)

Article

Patient drift and response-adaptive randomisation: impact and solutions

Sofia S Villar, James Wason, Jack Bowden in Trials (2015)

Article

Type I error control in biomarker-stratified clinical trials

Deepak Parashar, Jack Bowden, Colin Starr, Lorenz Wernisch, Adrian Mander in Trials (2015)

Article

Revisiting the multi-armed bandit model for the optimal design of clinical trials: benefits and drawbacks

Sofia S Villar, Jack Bowden, James Wason in Trials (2013)

Article

Impact of lack-of-benefit stop** rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome

Babak Choodari-Oskooei, Max KB Parmar, Patrick Royston, Jack Bowden in Trials (2013)

Article

Adaptive enrichment in biomarker-stratified clinical trial design

Deepak Parashar, Jack Bowden, Colin Starr, Lorenz Wernisch, Adrian Mander in Trials (2013)

Article

Impact of lack-of-benefit stop** rules on treatment effect estimates of two-arm multi-stage (TAMS) trials with time to event outcome

In 2011, Royston et al. described technical details of a two-arm, multi-stage (TAMS) design. The design enables a trial to be stopped part-way through recruitment if the accumulating data suggests a lack of benef...

Babak Choodari-Oskooei, Mahesh KB Parmar, Patrick Royston, Jack Bowden in Trials (2013)

Article

Designing a preliminary adaptive study to inform a biomarker trial in Psoriasis

Andrew T Prevost, Jack Bowden in Trials (2011)