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Open Accessi-shaped antibody engineering enables conformational tuning of biotherapeutic receptor agonists
The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediator...
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Open AccessMICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
One of the mechanisms by which tumors evade immune surveillance is through shedding of the major histocompatibility complex (MHC) class I chain-related protein A and B (MICA/B) from their cell surface. MICA/B ...
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Open AccessA targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies
Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux. Escherichia coli BamA is an essential component of the OMP β...
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Open AccessOptimizing antibody expression by using the naturally occurring framework diversity in a live bacterial antibody display system
Rapid identification of residues that influence antibody expression and thermostability is often needed to move promising therapeutics into the clinic. To establish a method that can assess small expression di...
