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  1. Article

    Open Access

    Coordinated wound responses in a regenerative animal-algal holobiont

    Animal regeneration involves coordinated responses across cell types throughout the animal body. In endosymbiotic animals, whether and how symbionts react to host injury and how cellular responses are integrat...

    Dania Nanes Sarfati, Yuan Xue, Eun Sun Song, Ashley Byrne in Nature Communications (2024)

  2. Article

    Open Access

    i-shaped antibody engineering enables conformational tuning of biotherapeutic receptor agonists

    The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediator...

    Matthew G. Romei, Brandon Leonard, Zachary B. Katz, Daniel Le in Nature Communications (2024)

  3. No Access

    Article

    Local models for Galois deformation rings and applications

    We construct projective varieties in mixed characteristic whose singularities model, in generic cases, those of tamely potentially crystalline Galois deformation rings for unramified extensions of ...

    Daniel Le, Bao V. Le Hung, Brandon Levin, Stefano Morra in Inventiones mathematicae (2023)

  4. No Access

    Article

    Human melanocyte development and melanoma dedifferentiation at single-cell resolution

    In humans, epidermal melanocytes are responsible for skin pigmentation, defence against ultraviolet radiation and the deadliest common skin cancer, melanoma. Although there is substantial overlap in melanocyte...

    Rachel L. Belote, Daniel Le, Ashley Maynard, Ursula E. Lang in Nature Cell Biology (2021)

  5. Article

    Open Access

    Delineating patterns of sexualized substance use and its association with sexual and mental health outcomes among young gay, bisexual and other men who have sex with men in Singapore: a latent class analysis

    Young gay, bisexual, and other men who have sex with men (YMSM) are vulnerable to the risks associated with sexualized substance use. This is a novel study in Singapore that aims to classify patterns of sexual...

    Rayner Kay ** Tan, Caitlin Alsandria O’Hara, Wee Ling Koh, Daniel Le in BMC Public Health (2021)

  6. Article

    Open Access

    Two year follow up of supercapsular percutaneously assisted total hip arthroplasty

    Dislocation after primary total hip arthroplasty (THA) has an incidence of 2–3%. Approximately 77% of dislocations occur within the first year after surgery. The SuperPATH technique is a minimally invasive app...

    Andrew Kay, Derek Klavas, Varan Haghshenas, Mimi Phan in BMC Musculoskeletal Disorders (2021)

  7. Article

    Open Access

    Association between sexual orientation acceptance and suicidal ideation, substance use, and internalised homophobia amongst the pink carpet Y cohort study of young gay, bisexual, and queer men in Singapore

    Gay, bisexual and queer (GBQ) men are frequently subjected to minority stressors that have negative impacts on their health. Milestones that include the acceptance and disclosure of sexual identity amongst GBQ...

    Clarence Ong, Rayner Kay ** Tan, Daniel Le, Avin Tan, Adrian Tyler in BMC Public Health (2021)

  8. Article

    Open Access

    Social capital and chemsex initiation in young gay, bisexual, and other men who have sex with men: the pink carpet Y cohort study

    Young gay, bisexual, and other men who have sex with men (YMSM) are especially vulnerable to the risks associated with sexualized substance use, or ‘chemsex’. Engaging in chemsex established as a major risk fa...

    Rayner Kay ** Tan, Caitlin Alsandria O’Hara in Substance Abuse Treatment, Prevention, and… (2021)

  9. No Access

    Article

    Lattices in the cohomology of U(3) arithmetic manifolds

    Under hypotheses required for the Taylor–Wiles method, we prove for forms of U(3) which are compact at infinity that the lattice structure on upper alcove algebraic vectors or on principal series types given by t...

    Daniel Le in Mathematische Annalen (2018)

  10. No Access

    Article

    Potentially crystalline deformation rings and Serre weight conjectures: shapes and shadows

    We prove the weight part of Serre’s conjecture in generic situations for forms of U(3) which are compact at infinity and split at places dividing p as conjectured by Herzig (Duke Math J 149(1):37–116, 2009). We a...

    Daniel Le, Bao V. Le Hung, Brandon Levin, Stefano Morra in Inventiones mathematicae (2018)

  11. No Access

    Article

    Locating and parsing bibliographic references in HTML medical articles

    The set of references that typically appear toward the end of journal articles is sometimes, though not always, a field in bibliographic (citation) databases. But even if references do not constitute such a fi...

    Jie Zou, Daniel Le, George R. Thoma in International Journal on Document Analysis… (2010)

  12. Article

    Open Access

    Glucose Toxicity: a case report

    Toxicity to glucose is not a normal state, however, it has been reported that after certain individuals ingest sugar, they produce excess tumor necrosis factor.

    Stanley S Lefkowitz, Doris L Lefkowitz, Daniel Le, Greg Charles in Cases Journal (2008)

  13. Chapter and Conference Paper

    Text Verification in an Automated System for the Extraction of Bibliographic Data

    An essential stage in any text extraction system is the manual verification of the printed material converted by OCR. This proves to be the most labor-intensive step in the process. In a system built and deplo...

    George R. Thoma, Glenn Ford, Daniel Le, Zhirong Li in Document Analysis Systems V (2002)