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  1. No Access

    Article

    Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons

    Argyrophilic grains (ArG) and coiled bodies of argyrophilic grain disease (AgD) and the neurofibrillary lesions of Alzheimer’s disease (AD) share similar antigenic determinants, among them hyperphosphorylated...

    M. Tolnay, M. G. Spillantini, M. Goedert, J. Ulrich, D. Langui… in Acta Neuropathologica (1997)

  2. Article

    Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain

    L. Harms, A. Bock, W. JÄnisch, J. Valdueza, J. Weber, I. Link… in Journal of Neurology (1994)

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  3. No Access

    Article

    Molecular neuroanatomy of monoamine oxidases in human brainstem

    Specific, high-resolution techniques (quantitative enzyme radioautography and in situ hybridisation histochemistry) have revealed distribution, abundance and cellular localisation of the isoenzymes MAO-A and M...

    J. G. Richards, J. Saura, J. Ulrich, M. Da Prada in Psychopharmacology (1992)

  4. No Access

    Article

    Deposition of β/A4 protein along neuronal plasma membranes in diffuse senile plaques

    The origin of the extracellular β-amyloid protein (β/A4) found in senile plaques and the cellular mechanisms responsible for its deposition in cerebral tissues are still an unresolved issue in Alzheimer's dise...

    A. Probst, D. Langui, S. Ipsen, N. Robakis, J. Ulrich in Acta Neuropathologica (1991)

  5. No Access

    Article

    Senile plaques: staining for acetylcholinesterase and A4 protein: a comparative study in the hippocampus and entorhinal cortex

    In 20 unselected autopsy cases tissue blocks from the hippocampus with adjacent entorhinal cortex and neocortex were stained for acetylcholinesterase (AChE). From five brains shown to have large numbers of sen...

    J. Ulrich, W. Meier-Ruge, A. Probst, E. Meier, S. Ipsen in Acta Neuropathologica (1990)

  6. No Access

    Article

    Aluminium-induced tangles in cultured rat neurones

    Neurofilamentous tangles have been induced in cultured neurones from rat brain hemispheres by application of both aluminium and maltol. Quantitative evaluation revealed a significantly higher percentage of tan...

    D. Langui, A. Probst, B. Anderton, J. -P. Brion, J. Ulrich in Acta Neuropathologica (1990)

  7. No Access

    Article

    Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex

    Although much work has been directed recently towards unravelling the protein chemistry of neurofibrillary tangle (NFT) and senile plaque (SP) components in Alzheimer's disease, the pathogeneses of these lesio...

    A. Probst, B. H. Anderton, J. -P. Brion, J. Ulrich in Acta Neuropathologica (1989)

  8. No Access

    Chapter and Conference Paper

    Epitopes Characteristic of Paired Helical Filaments Demonstrated in Microglial Cells and Macrophages of the Meninges: A Possible Laboratory Diagnosis of Alzheimer’s Disease from Cerebrospinal Fluid?

    In AD microglial cells were known for a long time to be present in the senile plaque. Here we demonstrate that in AD a minority of the microglial cells in the neocortex and in the hippocampus can be immunostai...

    J. Ulrich, S. Ipsen, A. Probst, J. P. Brion in Biological Markers of Alzheimer’s Disease (1989)

  9. No Access

    Article

    Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles

    Light microscopic immunohistochemical investigations were performed on neurofibrillary tangles (NFT) in four histologically confirmed cases of Alzheimer's disease (AD) and in five patients with a progressive s...

    A. Probst, D. Langui, C. Lautenschlager, J. Ulrich, J. P. Brion… in Acta Neuropathologica (1988)

  10. No Access

    Article

    Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes

    Section of formaldehyde-fixed paraffinembedded cortical and hippocampal brain tissue from five cases with senile dementia of Alzheimer type (SDAT) and five cases with Pick's disease (PD) were immunostained wit...

    J. Ulrich, M. Haugh, B. H. Anderton, A. Probst, C. Lautenschlager… in Acta Neuropathologica (1987)

  11. No Access

    Article

    A special type of senile plaque, possibly an initial stage

    It is customary to distinguish “primitive”, “classic” and “compact” (“burned out”) senile plaques in Alzheimer's disease and senile dementia of the Alzheimer type (SDAT). Primitive plaques are characterized by...

    A. Probst, H. Brunnschweiler, C. Lautenschlager, J. Ulrich in Acta Neuropathologica (1987)

  12. No Access

    Article

    The brain diseases causing senile dementia

    Brains from 54 patients with organic dementia were examined systematically. As in previous investigations a predominance of Alzheimer type changes was observed. Seventeen patients showed Lewy bodies in the nuc...

    J. Ulrich, A. Probst, M. Wüest in Journal of Neurology (1986)

  13. No Access

    Article

    Pick's disease: An immunocytochemical study of neuronal changes

    We used rabbit antisera to the 210,000; 155,000; and 70,000 mol. wt. neurofilament — polypeptides and monoclonal antibodies (BF 10; RT 97) known to react with human neurofilaments in an immunohistochemical stu...

    A. Probst, B. H. Anderton, J. Ulrich, R. Kohler, J. Kahn… in Acta Neuropathologica (1983)

  14. No Access

    Article

    Immunocytochemical investigations of some human leukodystrophies

    One case of each of the following human leukodystrophies was examined immunocytochemically with antisera against myelin basic protein (MBP), myelin associated glycoprotein (MAG) and gliofibrillary acidic prote...

    J. Ulrich, R. Kohler, Ph. U. Heitz, A. Probst in Acta Neuropathologica (1983)

  15. No Access

    Article

    Evidence for a chronic axonal atrophy in oculopharyngeal “muscular dystrophy”

    We report on morphometric investigations of peripheral nerves in a woman, who died at the age of 69, presenting the classical symptoms of oculopharyngeal muscular dystrophy (OPMD) and a typical family history ...

    A. Probst, W. Tackmann, H. R. Stoeckli, F. Jerusalem, J. Ulrich in Acta Neuropathologica (1982)

  16. No Access

    Article

    Senile dementia of Alzheimer type: Astroglial reaction to extracellular neurofibrillary tangles in the hippocampus

    Two types of Alzheimer neurofibrillary tangles may be found in the hippocampus in senile dementia of the Alzheimer type. Besides classical flameshaped intraneuronal tangles, there are less compact tangles repr...

    A. Probst, J. Ulrich, Ph. U. Heitz in Acta Neuropathologica (1982)

  17. No Access

    Article

    Experimental allergic encephalomyelitis

    Classical acute allergic encephalomyelitis (EAE) was provoked in Lewis rats with bovine spinal cord (BWM) in complete Freund's adjuvant (CFA). An efficient immunohistologic technique (peroxidase-antiperoxidase...

    H. P. Ackermann, J. Ulrich, Ph. U. Heitz in Acta Neuropathologica (1981)

  18. No Access

    Article

    Connatal polyneuropathy — A case with proliferated microfilaments in schwann cells

    A case of connatal polyneuropathy is described in a boy who died of pneumonia at the age of 2 years, and from whom sural nerve biopsies had been taken when he was 4 and 16 months old. Clinically, his disease w...

    J. Ulrich, H. -R. Hirt, P. Kleihues, M. Oberholzer in Acta Neuropathologica (1981)

  19. No Access

    Article

    Adrenomyeloneuropathy

    Histopathological, immunocytochemical, and electron microscopical investigations were carried out in a man with a protracted history of spastic paraparesis, adrenal insufficiency and hypogonadism. Pathological...

    A. Probst, J. Ulrich, Ph. U. Heitz, N. Herschkowitz in Acta Neuropathologica (1980)

  20. No Access

    Article

    Multiple sclerosis: Demyelination and myelination inhibition of organotypic tissue cultures of the spinal cord by sera of patients with Multiple Sclerosis and other neurological diseases

    Sera from 44 patients with Multiple Sclerosis, of three patients with neurological syndromes compatible with Multiple Sclerosis, of 34 patients suffering from other neurological diseases and of 25 pregnant hea...

    J. Ulrich, Helga Lardi in Journal of Neurology (1978)

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