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Article
Physiological and pathological properties of α-synuclein
α-Synuclein belongs to a small group of natively unfolded proteins that can transiently bind to lipid membranes and acquire a partial α-helical conformation. Under certain pathogenic conditions, α-synuclein ag...
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Article
A novel leukoencephalopathy associated with tau deposits primarily in white matter glia
A 79-year-old woman had a 10-year history of dementia, initially presenting as non-fluent aphasia. Magnetic resonance imaging showed frontal atrophy (left greater than right) and hyperintense foci within white...
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Article
Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
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Article
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
Coding region and intronic mutations in the tau gene cause frontotemporal dementia and parkinsonism linked to chromosome 17. Some of these mutations lead to an overproduction of tau isoforms with four microtu...
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Chapter and Conference Paper
Tauopathies and α-Synucleinopathies
Alzheimer’s disease and Parkinson’s disease are the most common neurodegenerative diseases of the human brain. They are characterized by the presence of ordered filamentous assemblies that gradually develop in...
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Article
Microtubule-associated protein tau, heparan sulphate and α-synuclein in several neurodegenerative diseases with dementia
Microtubule-associated protein tau forms neurofibrillary lesions in Alzheimer’s disease and several other neurodegenerative disorders, such as Niemann-Pick disease type C, subacute sclerosing panencephalitis,...
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Article
Tau gene mutation in familial progressive subcortical gliosis
Familial forms of frontotemporal dementias are associated with mutations in the tau gene. A kindred affected by progressive subcortical gliosis (PSG), a rare form of presenile dementia, has genetic linkage to chr...
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Article
Lewy body diseases and multiple system atrophy as α-synucleinopathies
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Article
Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons
Argyrophilic grains (ArG) and coiled bodies of argyrophilic grain disease (AgD) and the neurofibrillary lesions of Alzheimer’s disease (AD) share similar antigenic determinants, among them hyperphosphorylated...
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Article
Pick’s disease: hyperphosphorylated tau protein segregates to the somatoaxonal compartment
Pick bodies and ballooned cells of Pick’s disease and the neurofibrillary lesions of Alzheimer’s disease are characterized by the presence of hyperphosphorylated microtubule-associated protein tau. Little is ...
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Article
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans
THE paired helical filament (PHF) is the major component of the neurofibrillary deposits that form a defining neuropathological characteristic of Alzheimer's disease (reviewed in refs 1,2). PHFs are composed ...
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Article
Comparison of the neurofibrillary pathology in Alzheimer’s disease and familial presenile dementia with tangles
Alzheimer’s disease (AD) is characterised neuropathologically by the presence of abundant extracellular β-amyloid deposits and intracellular neurofibrillary lesions consisting of neurofibrillary tangles, neur...
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Article
Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation?
In recent years the role of the peripheral nervous system has been focused on the pathogenesis of rheumatoid arthritis (RA). In particular, substance P (SP), released by the sensory terminals, has been demonst...
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Article
Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system
ALTHOUGH most proto-oncogenes such as c-myc are involved in cell proliferation, being expressed in a wide range of tissues as well as in progenitors of transformed cells1, others may normally function in cellular...
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Article
Molecular neuropathology of Alzheimer's disease:In situ hybridization studies
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Abundant senile plaques and neurofibrillary tangles in certain brain regions constitute the major neuropathol...
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Article
Measurement of catecholamines, met-enkephalin, somatostatin and substance P-like immunoreactivities in 12 human pheochromocytomas
The present study was designed to evaluate the simultaneous presence of epinephrine (E), norepinephrine (NE), met-enkephalin (ME)-, somatostatin (SRIF)- and substance P (SP)- like immunoreactivities (LI) in ex...
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Chapter and Conference Paper
HPLC and Immunohistochemical Characterization of Substance P-Like Immunoreactivity in a Human Pheochromocytoma
A case of human adrenal pheochromocytoma, containing elevated concentration of substance P-like immunoreactivity (SP-LI) (217 pmol/g) is described. In the peripheral plasma, however, SP-LI was (8.2 pmol/l) sim...
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Chapter and Conference Paper
Substance P Empty Neuron: A Conceptualization of Organic and Functional Deafferentation Syndromes
When the pain transmission in sensitive nerves is impaired or interrupted by a partial or total organic deafferentation (DFT) the following main events occur: a) lowering of SP content into the ipsimetameric d...
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Chapter and Conference Paper
Substance P- and Somatostatin-Like Immunoreactivity in Maternal and in Umbilical Cord Plasma and in Amniotic Fluid
Substance P containing neurons are present in the female reproductive organs. It has been reported that substance Plike- immunoreactivity (SP-LI) is decreased during pregnancy in maternal plasma as well as in ...
