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Article
Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3β inhibition and in neurons
Muscarinic agonists alter the metabolism of amyloid precursor protein, leading to an increase in α-secretase cleavage and a decreased production of amyloidogenic peptides; suggesting that these compounds migh...
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Article
Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation
The histological features of familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation (FAB) include deposition of amyloid, (supposedly associated with the C-terminal frag...
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Article
Relationships between Lewy bodies and pale bodies in Parkinson's disease
The prevalance of pale bodies and Lewy bodies was studied in the substantia nigra of 12 patients with typical Parkinson's disease (PD), in 5 patients with diffuse Lewy body disease (DLBD), and in a group of ne...
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Article
New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies
Ubiquitin has previously been identified as a component of neuronal inclusions in neurodegenerative disorders. In this investigation, we examined tissue from cases of Alzheimer's disease (AD), Pick's discase, ...
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Article
Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex
Although much work has been directed recently towards unravelling the protein chemistry of neurofibrillary tangle (NFT) and senile plaque (SP) components in Alzheimer's disease, the pathogeneses of these lesio...
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Article
Pathology of the neuronal cytoskeleton in Alzheimer's disease
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Article
Immunohistochemistry of plaques and tangles
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Chapter and Conference Paper
A cDNA Encodes Epitopes Shared Between Microtubule-Associated Protein MAP2 and Alzheimer Neurofibrillary Tangles: In Situ Hybridization and Immunocytochemistry
Neurofibrillary tangles in Alzheimer’s disease are composed of abnormal filaments whose biochemical composition is partly resolved. Cytoskeletal proteins are major components of these abnormal fibers, the micr...
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Chapter and Conference Paper
Genetics of Alzheimer’s Disease: Current Status and Future Development of Research
Alzheimer’s disease appears at present to be heterogeneous in regard to genetic factors, as well as in other respects. It is generally agreed that Alzheimer’s disease can show a familial tendency; however, it ...
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Article
Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles
Light microscopic immunohistochemical investigations were performed on neurofibrillary tangles (NFT) in four histologically confirmed cases of Alzheimer's disease (AD) and in five patients with a progressive s...
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Article
Alzheimer dementia and Pick's disease: neurofibrillary tangles and Pick bodies are associated with identical phosphorylated neurofilament epitopes
Section of formaldehyde-fixed paraffinembedded cortical and hippocampal brain tissue from five cases with senile dementia of Alzheimer type (SDAT) and five cases with Pick's disease (PD) were immunostained wit...
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Article
Staining with monoclonal antibodies to neurofilaments distinguishes between subpopulations of neurofibrillary tangles, between groups of axons and between groups of dendrites
A new monoclonal antibody (mab) against neurofilaments is described (mab 1215) and its reactions compared with previously characterized mabs (BF10; RT97). Mab 1215 recognizes an epitope on the heavy neurofilam...
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Chapter
Immunochemical Studies of the Relationship Between the Neuronal Cytoskeleton and Neurofibrillary Tangles
Two major types of pathological lesion are present in Alzheimer’s disease: the neurofibrillary tangle and the neuritic senile plaque. The presence of tangles in the cerebral cortex has a diagnostic significanc...
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Article
Dementia of alzheimer type (DAT) — a review of its morbid anatomy
The most important morphological findings in dementia of Alzheimer type (DAT) are Alzheimer neurofibrillary tangles, senile plaques, amyloid angiopathy, granulovacuolar degeneration and Hirano bodies. The morp...
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Chapter
The Neuronal Cytoskeleton and Neurofibrillary Tangles
Dementia of the Alzheimer type, or Alzheimer’s disease, has a characteristic brain histopathology comprising neurofibrillary tangles, senile neuritic plaques, granulovacuolar bodies and Hirano bodies. A correl...
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Chapter and Conference Paper
The Nature of Neurofibrillary Tangles
Dementia of the Alzheimer type (ATD), both presenile and senile, has a characteristic brain histopathology comprising neurofibrillary tangles (NFT), senile plaques, granulovacuolar bodies and Hirano bodies. Al...
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Article
Alterations in the organisation of cytokeratin filaments in normal and malignant human colonic epithelial cells during mitosis
An ultrastructural analysis of the organisation of 10 nm intermediate filaments during mitosis, in normal and malignant human colonic epithelial cells present in resected material, was carried out. Similar cha...
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Article
Pick's disease: An immunocytochemical study of neuronal changes
We used rabbit antisera to the 210,000; 155,000; and 70,000 mol. wt. neurofilament — polypeptides and monoclonal antibodies (BF 10; RT 97) known to react with human neurofilaments in an immunohistochemical stu...
