6 Result(s)
within
J. M. García-Martínez
-
Article
An efficient approach for solving the HP protein folding problem based on UEGO
This work applies the methodology of the Universal Evolutionary Global Optimization, UEGO, to solve the protein structure optimization problem based on the HP model. The UEGO algorithm was initially designed to s...
-
Article
A GPU implementation of a hybrid evolutionary algorithm: GPuEGO
The high computation requirements of global optimization algorithms, when used to solve real optimization problems, have caused the appearance of different parallelization strategies using several parallel com...
-
Article
Open AccessEffect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice
The PI3K–mTOR (phosphoinositide 3-kinase–mammalian target of rapamycin kinase) pathway is activated in the majority of tumours, and there is interest in assessing whether inhibitors of PI3K or mTOR kinase have...
-
Article
PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum
Dysregulation of gene expression is one of the mechanisms involved in the pathophysiology of Huntington's disease (HD). Here, we examined whether mutant huntingtin regulates the levels of PH domain leucine-ric...
-
Article
WNT/β-catenin increases the production of incretins by entero-endocrine cells
Glucose-dependent insulinotropic peptide (GIP) plays a pivotal role in the regulation of glucose homeostasis. Rates of diet-induced obesity, insulin resistance and type 2 diabetes are decreased when GIP signal...
-
Article
On the Changes in Glass Transition Temperatures of Atactic Polypropylenes Induced by Grafting of Polar Groups
A discussion on the influence of grafted polar groups (succinic anhydride and succinil-fluorescein) in glass transition behaviour of atactic polypropylene is shown in this work, on the basis of the reaction co...
