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  1. Article

    Open Access

    Imbalance of p75NTR/TrkB protein expression in Huntington’s disease: implication for neuroprotective therapies

    Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington’s disease (HD) treatment. However, our group has recently reported reduced levels of...

    V Brito, M Puigdellívol, A Giralt, D del Toro, J Alberch, S Ginés in Cell Death & Disease (2013)

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    Article

    BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease

    Brain-derived neurotrophic factor (BDNF) is the main candidate for neuroprotective therapeutic strategies for Huntington's disease. However, the administration system and the control over the dosage are still ...

    A Giralt, H C Friedman, B Caneda-Ferrón, N Urbán, E Moreno, N Rubio… in Gene Therapy (2010)

  3. Article

    PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum

    Dysregulation of gene expression is one of the mechanisms involved in the pathophysiology of Huntington's disease (HD). Here, we examined whether mutant huntingtin regulates the levels of PH domain leucine-ric...

    A Saavedra, J M García-Martínez, X **fró, A Giralt… in Cell Death & Differentiation (2010)

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