Sepsis Management
PIRO and MODS
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Article
Open AccessLong-term ileoanal pouch survival after pouch urinary tract fistulae
Ileoanal pouch is a demanding procedure with many potential technical complications including bladder or ureteral injury, while inflammation or stricture of the anastomosis or anal transition zone may lead to ...
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Article
Defining the safety of early ileostomy closure after ileal pouch anal anastomosis
The safety of early ileostomy reversal after ileal pouch anal anastomosis (IPAA) has not been established. Our hypothesis was that ileostomy reversal before 8 weeks is associated with negative outcomes.
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Article
Individualising Therapy to Minimize Bacterial Multidrug Resistance
The scourge of antibiotic resistance threatens modern healthcare delivery. A contributing factor to this significant issue may be antibiotic dosing, whereby standard antibiotic regimens are unable to suppress ...
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Chapter
Burn Patients and Blood Product Transfusion Practice: Time for a Consensus?
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Article
Open AccessESICM LIVES 2016: part one
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Article
Erratum to: Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients
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Article
Risk factors for target non-attainment during empirical treatment with β-lactam antibiotics in critically ill patients
Risk factors for β-lactam antibiotic underdosing in critically ill patients have not been described in large-scale studies. The objective of this study was to describe pharmacokinetic/pharmacodynamic (PK/PD) ...
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Article
Open AccessA limited set of molecular biomarkers may provide superior diagnostic outcomes to procalcitonin in sepsis
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Article
Open AccessA post-authorisation survey to analyse the perioperative teicoplanin plasma concentrations in adult patients with chronic bone sepsis, who received loading doses of 12 mg/kg 12-hourly for 48 hours followed by 12 mg/kg once daily
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Book
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Article
The role of surveillance cultures in the prediction of susceptibility patterns of Gram-negative bacilli in the intensive care unit
Surveillance cultures may detect colonisation with drug-resistant Gram-negative bacteria and can be hypothesised to guide appropriate initial antibiotic treatment for intensive care unit (ICU) patients. We inv...
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Article
A novel molecular biomarker diagnostic for the early detection of sepsis
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Article
Augmented renal clearance in traumatic brain injury
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Chapter
Augmented Renal Clearance: Unraveling the Mystery of Elevated Antibiotic Clearance
The prescription of pharmaceuticals in the critically ill represents a significant challenge, largely due to the scarcity of knowledge concerning the pharmacokinetic implications of the underlying disease state [
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Chapter and Conference Paper
Augmented Renal Clearance: Unraveling the Mystery of Elevated Antibiotic Clearance
The prescription of pharmaceuticals in the critically ill represents a significant challenge, largely due to the scarcity of knowledge concerning the pharmacokinetic implications of the underlying disease state [
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Article
Antibiotic dosing regimens for septic patients receiving continuous venovenous haemofiltration: do current studies supply sufficient data?
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Article
The single-staged approach to the surgical management of abdominal wall hernias in contaminated fields
The surgical treatment of large ventral hernias with accompanying contamination is challenging. We have reviewed our institution's experience with single-staged repair of complex ventral hernias in the setting...
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Article
Ciprofloxacin pharmacokinetic profiles in paediatric sepsis: how much ciprofloxacin is enough?
Objective: To determine the pharmacokinetic profile of ciprofloxacin 20 mg/kg per day (10 mg/kg administered intravenously 12 hourly) in paediatric patients with severe sepsis. Design: Open and p...
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Article
The Study of Influence of Metal Ions on Thermal Decomposition of Humic Acids
Investigations of the influence of the following metal ions: Ca, Mg, Ba, Cr, Mn,Co, Ni, Fe(II), Fe(III), Cu, Zn, Cd, Pb, Hg, Al and Ag on thermal decomposition of humic acids were carried out. Metal-humic comp...
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Article
Subcutaneous oxygen tensions provide similar information to ileal luminal CO2 tensions in an animal model of haemorrhagic shock
Objectives: The cutaneous and splanchnic circulations undergo early vasoconstriction in shock. Methodological problems and insufficient information on subcutaneous carbon dioxide partial...
