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Article
Open AccessEssential medicines containing ethanol elevate blood acetaldehyde concentrations in neonates
Neonates administered ethanol-containing medicines are potentially at risk of dose-dependent injury through exposure to ethanol and its metabolite, acetaldehyde. Here, we determine blood ethanol and acetaldehy...
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Article
Community pharmacy based provision of pharmaceutical care to older patients
Aim: To measure the outcomes of a harmonised, structured pharmaceutical care programme provided to elderly patients by community pharmacists.Method: A randomised, controlled, longitudinal, clinical trial with re...
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Chapter
Alternative Medicines and the Elderly
The term alternative medicine is one that can cover a range of topics and can mean many things to different audiences. For this particular chapter, focus has been placed on the use of “medicinal products” with...
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Article
Abuse/misuse of non‐prescription drugs
Aim: To investigate the abuse of non‐prescription (over‐the‐counter; OTC) products in Northern Ireland. Method: A structured questionnaire covering various aspects of OTC drug abuse was mailed to all 509 commu...
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Article
A self‐reported work sampling study in community pharmacy practice
Lack of time to implement pharmaceutical care has been cited as a barrier to the routine provision of this extended patient‐care service. Using self‐reported work sampling methodology, this study investigated ...
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Article
Buccal absorption of enalapril and lisinopril
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Article
Self-reported medication non-compliance in the elderly
Objective: To assess self-reported compliance with prescribed medications in a population of elderly patients prior to their hospital admission in an attempt to understand further the factors which influence dru...
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Article
A pharmacokinetic and pharmacodynamic evaluation of buffered sublingual captopril in patients with congestive heart failure
Objective: The pharmacokinetics and pharmacodynamics of buffered sublingual captopril were assessed in patients with congestive heart failure (CHF).
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Chapter
In Vitro Drug Interactions
In vitro drug interactions may be defined as those interactions which occur outside the body. Drug interactions which will be discussed in this chapter are those which occur between drugs due to reasons of inc...
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Chapter
Age and Genetic Factors in Drug Interactions
It has long been known that specific patient factors can influence the course of therapy and the adverse drug reactions and interactions that may follow (Wallace and Watanabe 1977; Ouslander 1981; Braverman 1982;...
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Chapter
Drug Interactions at Plasma and Tissue Binding Sites
The binding of drugs to plasma and tissue proteins is a major determinant of drug distribution throughout the body. This binding has also a very important effect on drug dynamics since it is only the free (unb...
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Article
The effect of pH on the buccal and sublingual absorption of captopril
The effect of pH on the buccal and sublingual absorption of captopril was evaluated using in vitro techniques and human studies. Partitioning of captopril into n-octanol was lowest over the pH range 5 to 8 and...
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Article
Sublingual captopril — a pharmacokinetic and pharmacodynamic evaluation
In this study we compared the pharmacokinetics and pharmacodynamics of captopril after sublingual and peroral administration. Single 25 mg doses of captopril were administered sublingually and perorally on two...
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Chapter
The pharmacokinetics of azapropazone
The subject of pharmacology can conveniently be divided into two subsections, namely pharmacodynamics and pharmacokinetics. While pharmacodynamics deals with the therapeutic effects (both desirable and undesir...
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Chapter
HPLC Analysis of Anti-Inflammatory Agents (Non-Steroidal and Steroidal)
AI* agents in biological fluids are commonly analyzed chromatographically, maybe by GC but usually by HPLC — typically RP — with UV detection (sometimes fluorescence or EC). HPLC is also convenient in percutan...
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Article
The chronopharmacokinetics of indomethacin suppositories in healthy volunteers
The pharmacokinetics of a single 100 mg indomethacin suppository were studied in 12 healthy volunteers on two occasions at least 7 days apart. Suppositories were administered in randomised order at 9.00 and 21...
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Article
The effect of dietary amino acids on the gastrointestinal absorption of melphalan and chlorambucil
Previous studies have demonstrated that the biovailability of melphalan and chlorambucil may be reduced under non-fasting conditions, and that the gastrointestinal and cellular absorption of melphalan is an ac...
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Chapter
Drug interactions between the anti-inflammatory drugs and with other agents
Although drug interactions have often been over-estimated and over-stated there still remains a spectrum of clinically relevant interactions involving drugs that are in common use. The antiinflammatory analges...
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Article
Studies on the mechanism of gastrointestinal absorption of melphalan and chlorambucil
The uptake of melphalan into tumour cells has been shown previously to involve active transport, while that of chlorambucil is by passive diffusion. In view of these findings, the mechanism of their gastrointe...
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Article
Dependence on Kaolin and Morphine Mixture, hypokalaemia and hypertension
A 31 year old male patient presented with profound hypokalaemia and was found to be hypertensive and addicted to Kaolin and Morphine Mixture BP. An in vitro study showed potassium binding to kaolin and the imp...
