-
Article
A novel mechanism regulating insulin secretion involving Herpud1 in mice
Type 2 diabetes results from beta cell dysfunction after prolonged physiological stress, which causes oversecretion of insulin. We recently found that insulin hypersecretion is mediated by at least two genes. ...
-
Article
Ketosis and appetite-mediating nutrients and hormones after weight loss
Diet-induced weight loss is accompanied by compensatory changes, which increase appetite and encourage weight regain. There is some evidence that ketogenic diets suppress appetite. The objective is to examine ...
-
Article
Estimating dual-energy X-ray absorptiometry-derived total body skeletal muscle mass using single-slice abdominal magnetic resonance imaging in obese subjects with and without diabetes: a pilot study
Single-slice abdominal computed tomography or magnetic resonance imaging (MRI) performed to measure visceral adipose tissue in individuals with obesity and diabetes mellitus can also image skeletal muscle. The...
-
Article
Persistenza a lungo termine degli adattamenti ormonali al calo ponderale
-
Article
A clinical trial assessing the safety and efficacy of the CB1R inverse agonist taranabant in obese and overweight patients: low-dose study
To evaluate the weight loss efficacy, safety and tolerability of taranabant, a CB1R inverse agonist, in obese and overweight patients.
-
Article
Symposia
-
Article
Insulin may have a role to play in protecting beta cells from deterioration in diabetes. Reply to Del Parigi A [letter]
-
Article
Too much of a good thing: why it is bad to stimulate the beta cell to secrete insulin
In many countries, first- or second-line pharmacological treatment of patients with type 2 diabetes consists of sulfonylureas (such as glibenclamide [known as glyburide in the USA and Canada]), which stimulate...
-
Article
Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes
Insulin hypersecretion may be an independent predictor of progression to type 2 diabetes. Identifying genes affecting insulin hypersecretion are important in understanding disease progression. We have previous...
-
Article
The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets
We determined whether high-glucose-induced beta cell dysfunction is associated with oxidative stress in the DBA/2 mouse, a mouse strain susceptible to islet failure.
-
Article
Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y
OBJECTIVE: Altered fat distribution is a consequence of menopause, but the mechanisms responsible are unknown. Estrogen insufficiency in humans can be modeled using ovariectomized rats. We have shown that increas...
-
Article
Differential and genetically separable associations of leptin with obesity-related traits
OBJECTIVE: The extent to which leptin protects against obesity is unknown. By intercrossing New Zealand obese mice with lean C57BL/6J mice, we have separated the genes controlling leptin and other weight-relat...
-
Article
Features of syndrome X develop in transgenic rats expressing a non-insulin responsive phosphoenolpyruvate carboxykinase gene
Aims/hypothesis. Obesity, glucose intolerance, dyslipidaemia and hypertension are a cluster of disorders (syndrome X) affecting many people. It has been hypothesised that these abnormalities are ...
-
Article
The set point for maternal glucose homeostasis is lowered during late pregnancy in the rat: the role of the islet beta-cell and liver
The aim of this study was to determine the effects of late pregnancy on the ability of insulin to suppress maternal hepatic glucose production in the rat. Unlike in most previous studies, suppression of hepati...
-
Article
The feto-placental glucose steal phenomenon is a major cause of maternal metabolic adaptation during late pregnancy in the rat
The aim of this study was to determine the extent to which a feto-placental glucose steal phenomenon contributes to the process of maternal metabolic adaptation to late pregnancy. Glucose metabolism was studie...
-
Article
Hyperinsulinaemia and insulin insensitivity: studies in subjects with insulinoma
Hepatic glucose turnover, peripheral insulin sensitivity and insulin receptor binding were measured in four subjects with insulinoma before and 3 months after surgical resection of the insulinoma. Basal hepati...
-
Article
Impaired insulin action in newly diagnosed type 1 (insulin-dependent) diabetes mellitus
Hepatic and peripheral insulin sensitivity were investigated in five newly diagnosed Type 1 (insulin-dependent) diabetic subjects before and after 1 week of twice daily insulin therapy. Eight weight-matched co...
-
Article
Glucose utilization in Type 1 (insulin-dependent) diabetes: Evidence for a defect not reversible by acute elevations of insulin
It has long been assumed that replacement of insulin in insulin-deficient diabetic patients will normalise glucose utilization. In this study, glucose utilization was measured in nine long-standing, poorly con...
-
Article
Insulin resistance in alloxan-diabetic dogs: Evidence for reversal following insulin therapy
Hepatic glucose production and peripheral glucose utilization were measured basally and during infusion of insulin (25 and 40 mU·kg-1·h-1) in normal dogs and in insulin-deficient diabetic dogs, before and after a...
-
Article
Differential effects of insulin therapy on hepatic and peripheral insulin sensitivity in Type 2 (non-insulin-dependent) diabetes
Hepatic glucose production and metabolic clearance rate of glucose were measured using (3-3H) glucose at steady state, basally and during two sequential 2 h insulin (25 and 40mU · kg–1 · h–1)/glucose(2 and 3mg · ...
