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Article
F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes
F13A1/FXIII-A transglutaminase has been linked to adipogenesis in cells and to obesity in humans and mice, however, its role and associated molecular pathways in human acquired excess weight have not been explore...
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Article
Adipose tissue mitochondrial capacity associates with long-term weight loss success
We investigated whether (1) subcutaneous adipose tissue (SAT) mitochondrial capacity predicts weight loss success and (2) weight loss ameliorates obesity-related SAT mitochondrial abnormalities.
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Article
Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss
Few studies have examined both gene expression and DNA methylation profiles in subcutaneous adipose tissue (SAT) during long-term weight loss. Thus, molecular mechanisms in weight loss and regain remain elusive.
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Article
Gene expression profile of subcutaneous adipose tissue in BMI-discordant monozygotic twin pairs unravels molecular and clinical changes associated with sub-types of obesity
Subcutaneous adipose tissue (SAT) undergoes major changes in obesity, but little is known about the whole-genome scale patterns of these changes or about their variation between different obesity sub-groups. W...
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Article
Biotin-dependent functions in adiposity: a study of monozygotic twin pairs
Biotin acts as a coenzyme for carboxylases regulating lipid and amino-acid metabolism. We investigated alterations of the biotin-dependent functions in obesity and the downstream effects of biotin restriction ...
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Article
DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs
Little is known about epigenetic alterations associated with subcutaneous adipose tissue (SAT) in obesity. Our aim was to study genome-wide DNA methylation and gene expression differences in SAT in monozygotic...
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Article
A break in the obesity epidemic? Explained by biases or misinterpretation of the data?
Recent epidemiologic papers are presenting prevalence data suggesting breaks and decreases in obesity rates. However, before concluding that the obesity epidemic is not increasing anymore, the validity of the ...
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Article
Adipocyte morphology and implications for metabolic derangements in acquired obesity
Adipocyte size and number have been suggested to predict the development of metabolic complications in obesity. However, the genetic and environmental determinants behind this phenomenon remain unclear.
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Article
Characterising metabolically healthy obesity in weight-discordant monozygotic twins
Not all obese individuals display the metabolic disturbances commonly associated with excess fat accumulation. Mechanisms maintaining this ‘metabolically healthy obesity’ (MHO) are as yet unknown. We aimed to ...
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Article
CB1 blockade-induced weight loss over 48 weeks decreases liver fat in proportion to weight loss in humans
Studies in mice have suggested that endocannabinoid blockade using the cannabinoid receptor type 1 (CB1) blocker rimonabant prevents obesity-induced hepatic steatosis.
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Article
Erratum: Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
Correction to: International Journal of Obesity 36: 843–854; doi:10.1038/ijo.2011.158 Since publication of this article the authors have noticed the following errors. The original article has not been amended ...
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Article
Causes and consequences of obesity: the contribution of recent twin studies
Obesity is a genetically complex disorder that produces a myriad of health problems. Most of the recognized complications of obesity are not only strongly influenced by lifestyle factors, but also present with...
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Article
Erratum: Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analogue, liraglutide
Correction to: International Journal of Obesity advance online publication 16 August 2011; doi: 10.1038/ijo.2011.158 Since the publication of this article the authors have noticed an error in one of the figure...
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Article
Open AccessSafety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide
Having demonstrated short-term weight loss with liraglutide in this group of obese adults, we now evaluate safety/tolerability (primary outcome) and long-term efficacy for sustaining weight loss (secondary out...
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Article
Does dieting make you fat? A twin study
To investigate whether the paradoxical weight gain associated with dieting is better related to genetic propensity to weight gain than to the weight loss episodes themselves.
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Article
A clinical trial assessing the safety and efficacy of the CB1R inverse agonist taranabant in obese and overweight patients: low-dose study
To evaluate the weight loss efficacy, safety and tolerability of taranabant, a CB1R inverse agonist, in obese and overweight patients.
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Article
Inaccuracies in food and physical activity diaries of obese subjects: complementary evidence from doubly labeled water and co-twin assessments
To study whether eating or physical-activity (PA) habits differ between obese and non-obese monozygotic (MZ) co-twins independent of genetic effects.
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Article
Genetic and environmental effects on body mass index during adolescence: a prospective study among Finnish twins
To study genetic and environmental factors affecting body mass index (BMI) and BMI phenotypic correlations across adolescence.
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Article
Physical activity reduces the influence of genetic effects on BMI and waist circumference: a study in young adult twins
Both obesity and exercise behavior are influenced by genetic and environmental factors. However, whether obesity and physical inactivity share the same genetic vs environmental etiology has rarely been studied...
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Article
Eating styles, overweight and obesity in young adult twins
To explore the association of eating styles with overweight and obesity in young adults, controlling for identical genetic background in monozygotic twins.
