![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
The Aryl Hydrocarbon Receptor, Epigenetics and the Aging Process
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, classically associated with the regulation of xenobiotic metabolism in response to environmental toxins. In recent years, transge...
-
Article
Open AccessGenome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D
Affecting about 1 in 12 Americans annually, depression is a leading cause of the global disease burden. While a range of effective antidepressants are now available, failure and relapse rates remain substantia...
-
Article
Genome-wide association study of antipsychotic-induced QTc interval prolongation
QT prolongation is associated with increased risk of cardiac arrhythmias. Identifying the genetic variants that mediate antipsychotic-induced prolongation may help to minimize this risk, which might prevent th...
-
Article
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs
Understanding individual differences in the susceptibility to metabolic side effects as a response to antipsychotic therapy is essential to optimize the treatment of schizophrenia. Here, we perform genomewide ...
-
Article
Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics
Schizophrenia is an often devastating neuropsychiatric illness. Understanding the genetic variation affecting response to antipsychotics is important to develop novel diagnostic tests to match individual schiz...
-
Article
Microbial genetics: Split genes uncovered through science fusion