22 Result(s)

Article

Impact of the presence of HLA 1-locus mismatch and the use of low-dose antithymocyte globulin in unrelated bone marrow transplantation

HLA 1-locus-mismatched unrelated donors (1MMUD) have been used in allogeneic hematopoietic stem cell transplantation (allo-HCT) for patients who lack an HLA-matched donor. We retrospectively analyzed 3313 pati...

K Kawamura, J Kanda, S Fuji, M Murata, K Ikegame, K Yoshioka… in Bone Marrow Transplantation (2017)

Article

GvHD prophylaxis after single-unit reduced intensity conditioning cord blood transplantation in adults with acute leukemia

To investigate better GVHD prophylaxis in reduced intensity conditioning umbilical cord blood transplantation (RIC-UCBT), we compared transplant outcomes after UCBT among GvHD prophylaxes using the registry da...

S Terakura, Y Kuwatsuka, S Yamasaki, A Wake, J Kanda… in Bone Marrow Transplantation (2017)

Article

Impact of graft-versus-host disease on outcomes after unrelated cord blood transplantation

The effect of graft-versus-host disease (GVHD) on transplant outcomes after unrelated cord blood transplantation (UCBT) has not been fully elucidated. We analyzed the impact of acute and chronic GVHD on outcom...

J Kanda, Y Morishima, S Terakura, A Wake, N Uchida, S Takahashi, Y Ono… in Leukemia (2017)

Article

Risk factors and prognosis of hepatic acute GvHD after allogeneic hematopoietic cell transplantation

Hepatic acute GvHD (aGvHD) is associated with high mortality owing to poor response to immunosuppressive therapy. The pathogenesis of hepatic aGvHD differs from that of other lesions, and specific risk factors...

Y Arai, J Kanda, H Nakasone, T Kondo, N Uchida, T Fukuda… in Bone Marrow Transplantation (2016)

Article

Economic evaluation of a preemptive treatment strategy for invasive fungal infection in neutropenic patients with hematological diseases

We compared the expected medical costs of empirical and preemptive treatment strategies for invasive fungal infection in neutropenic patients with hematological diseases. Based on the results of two clinical t...

S.-I. Kimura, T. Murata, Y. Akahoshi… in European Journal of Clinical Microbiology … (2015)

Article

Impact of conditioning intensity and TBI on acute GVHD after hematopoietic cell transplantation

The impact of the conditioning intensity and TBI on acute GVHD (aGVHD) is still a matter of debate. We analyzed 6848 adult recipients who received allogeneic hematopoietic cell transplants (HCT) between 2006 a...

H Nakasone, T Fukuda, J Kanda, T Mori, S Yano, T Kobayashi… in Bone Marrow Transplantation (2015)

Article

Impact of HLA allele mismatch on the clinical outcome in serologically matched related hematopoietic SCT

In unrelated hematopoietic SCT (HSCT), HLA allele mismatch has been shown to have a significant role. To clarify the importance of HLA allele mismatch in the GVH direction in related HSCT, we retrospectively e...

S Fuji, J Kanda, S Kato, K Ikegame, S Morishima, T Miyamoto… in Bone Marrow Transplantation (2014)

Article

Prediction of infectious complications by the combination of plasma procalcitonin level and localized infection before allogeneic hematopoietic cell transplantation

We previously reported that the baseline C-reactive protein level did not predict infectious events after hematopoietic cell transplantation (HCT). Procalcitonin (PCT) has recently emerged as a powerful biomar...

M Sato, H Nakasone, K Terasako-Saito, K Sakamoto, R Yamazaki… in Bone Marrow Transplantation (2014)

Article

Risk factors and organ involvement of chronic GVHD in Japan

Few studies have evaluated the risk factors for chronic GVHD and organ involvement associated with different graft types, including unrelated cord blood (U-CB). We retrospectively studied 4818 adult patients w...

J Kanda, H Nakasone, Y Atsuta, T Toubai, H Yokoyama… in Bone Marrow Transplantation (2014)

Article

Single-cell T-cell receptor-β analysis of HLA-A*2402-restricted CMV- pp65-specific cytotoxic T-cells in allogeneic hematopoietic SCT

Cellular immunity is important for the control of CMV infection after allogeneic hematopoietic cell transplantation (Allo-HCT). However, the actual in vivo dynamics of CMV-specific cytotoxic T cell (CMV-CTL) clon...

H Nakasone, Y Tanaka, R Yamazaki, K Terasako, M Sato… in Bone Marrow Transplantation (2014)

Article

Outcomes and costs of autologous stem cell mobilization with chemotherapy plus G-CSF vs G-CSF alone

Chemotherapy plus G-CSF (C+G) and G-CSF alone are two of the most common methods used to mobilize CD34⁺ cells for autologous hematopoietic SCT (AHSCT). In order to compare and determine the real-world outcomes an...

A D Sung, D T Grima, L M Bernard, S Brown, G Carrum… in Bone Marrow Transplantation (2013)

Article

Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment

High fevers and/or rashes prior to neutrophil engraftment are frequently observed after umbilical cord blood (UCB) transplantation, and the condition is referred to as pre-engraftment syndrome (PES). Few studi...

J Kanda, L Kaynar, Y Kanda, V K Prasad, S H Parikh, L Lan… in Bone Marrow Transplantation (2013)

Article

Prediction of transplant-related complications by C-reactive protein levels before hematopoietic SCT

Various biomarkers have been investigated with regard to their ability to predict the outcome of allogeneic hematopoietic SCT (HSCT). In this study, we retrospectively reviewed 90 recipients who received HSCT ...

M Sato, H Nakasone, K Oshima, Y Ishihara, H Wada, K Sakamoto… in Bone Marrow Transplantation (2013)

Article

Unrelated cord blood transplantation vs related transplantation with HLA 1-antigen mismatch in the graft-versus-host direction

Little information is available regarding whether an unrelated cord blood (UCB) unit or a related donor with a 1-antigen mismatch at the HLA-A, HLA-B or HLA-DR locus in the graft-versus-host direction (RD/1AG-...

J Kanda, T Ichinohe, S Kato, N Uchida, S Terakura, T Fukuda, M Hidaka, Y Ueda… in Leukemia (2013)

Article

Hyperbilirubinemia in the early phase after allogeneic HSCT: prognostic significance of the alkaline phosphatase/total bilirubin ratio

Hyperbilirubinemia in the early phase after allogeneic hematopoietic SCT (HSCT) is due to various causes. One of the most important causes of hyperbilirubinemia is veno-occlusive disease/sinusoidal obstructive...

M Ashizawa, K Oshima, H Wada, Y Ishihara, K Kawamura… in Bone Marrow Transplantation (2013)

Article

Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation

Primary graft failure after allogeneic hematopoietic cell transplantation is a life-threatening complication. A shortened conditioning regimen may reduce the risk of infection and increase the chance of surviv...

J Kanda, M E Horwitz, G D Long, C Gasparetto, K M Sullivan… in Bone Marrow Transplantation (2012)

Article

Pretransplant serum ferritin and C-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation

Although fluoroquinolones or other antibiotics are commonly used to prevent bacterial infections after hematopoietic cell transplantation (HCT), because of the growing presence of multidrug-resistant microorga...

J Kanda, C Mizumoto, T Ichinohe, H Kawabata, T Saito… in Bone Marrow Transplantation (2011)

Article

Impact of discontinuing fluoroquinolone prophylaxis on early mortality after allogeneic marrow or peripheral blood SCT with myeloablative conditioning

J Kanda, T Ichinohe, T Saito, K Yamashita, T Kondo… in Bone Marrow Transplantation (2010)

Article

Long-term survival after HLA-haploidentical SCT from noninherited maternal antigen-mismatched family donors: impact of chronic GVHD

J Kanda, T Ichinohe, C Shimazaki, M Hamaguchi, A Watanabe… in Bone Marrow Transplantation (2009)