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β-D-Mannose Based Peptidomimetics in the Design of α4ß1 and α4β7 Antagonists
Interfering protein-protein interaction by small non-peptidic molecules is one of the great challenges in medicinal chemistry. The use of rigid scaffolds to generate peptidomimetics was first proposed by Fanne...
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Peptidic Inhibitors for Protein-Protein Interactions at Cell Surfaces
Interactions at cell surfaces are involved in a number of regulatory functions in living systems and therefore represent interesting drug targets such as the development of cyclic peptides and peptidomimetics ...
