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Article
Open AccessCurbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
The occurrence and spread of multidrug-resistant pathogens, especially bacteria from the ESKAPE panel, increases the risk to succumb to untreatable infections. We developed a novel antimicrobial peptide, Pam-3...
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Article
Open AccessThe main pulmonary artery in adults: a controlled multicenter study with assessment of echocardiographic reference values, and the frequency of dilatation and aneurysm in Marfan syndrome
Echocardiographic upper normal limits of both main pulmonary artery (MPA) diameters (MPA-d) and ratio of MPA to aortic root diameter (MPA-r) are not defined in healthy adults. Accordingly, frequency of MPA dil...
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Article
Open AccessPut a tiger in your tank: the polyclad flatworm Maritigrella crozieri as a proposed model for evo-devo
Polyclad flatworms are an early branching clade within the rhabditophoran Platyhelminthes. They provide an interesting system with which to explore the evolution of development within Platyhelminthes and among...
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Article
Open AccessCulture models to study leukocyte trafficking across the choroid plexus
A critical point during the course of central nervous system infection is the influx of leukocytes from the blood into the brain across the blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (...
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Article
Open AccessTranscellular migration of neutrophil granulocytes through the blood-cerebrospinal fluid barrier after infection with Streptococcus suis
A critical point during the course of bacterial meningitis is the excessive influx of polymorphnuclear neutrophils (PMNs) from the blood into the brain. Both paracellular and transcellular routes of leukocyte ...
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Article
The changing scene of allogeneic stem cell transplantation for chronic myeloid leukemia—a report from the German Registry covering the period from 1998 to 2004
Due to the recent changes in the indication to allogeneic stem cell transplantation (SCT) in chronic myeloid leukemia (CML), we retrospectively analyzed 1,716 patients with different CML stages who received an...
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Article
Differences in complication rates among the centres in the SPACE study
Despite the high grade of standardisation of study protocols, there is still room for variability among the centres in specific treatment aspects. We evaluated the treatment risk in stent-protected angioplasty...
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Article
Open AccessCuticle differentiation in the embryo of the amphipod crustacean Parhyale hawaiensis
The arthropod cuticle is a multilayered extracellular matrix produced by the epidermis during embryogenesis and moulting. Molecularly and histologically, cuticle differentiation has been extensively investigat...
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Chapter and Conference Paper
Anti Thymocyte Globuline Allows for Successful Transplantation from HLA Mismatched Unrelated Donors
Allogeneic hemopoietic stem cell transplantation of matched unrelated donors carries an increased risk of graft versus host disease (GvHD) and transplant related mortality (TRM). We introduced ATG Fresenius at...
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Article
Helicobacter exploits integrin for type IV secretion and kinase activation
Integrins are important mammalian receptors involved in normal cellular functions as well as pathogenesis of chronic inflammation and cancer. We propose that integrins are exploited by the gastric pathogen and...
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Article
Thrombin causes the Enrichment of Rat Brain Primary Cultures with Ependymal Cells Via Protease-Activated Receptor 1
Ependymal cell culture models from rat have been developed over the last 20 years to facilitate biochemical studies on this least-studied glial cell type. The cell culture protocol calls for the presence of th...
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Article
Open AccessSolvent exposure and malignant lymphoma: a population-based case-control study in Germany
To analyze the relationship between exposure to chlorinated and aromatic organic solvents and malignant lymphoma in a multi-centre, population-based case-control study.
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Article
Open AccessMortality and life expectancy of professional fire fighters in Hamburg, Germany: a cohort study 1950 – 2000
The healthy worker effect may hide adverse health effects in hazardous jobs, especially those where physical fitness is required. Fire fighters may serve as a good example because they sometimes are severely e...
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Article
Open AccessExplaining computation of predictive values: 2 × 2 table versus frequency tree. A randomized controlled trial [ISRCTN74278823]
Involving patients in decision making on diagnostic procedures requires a basic level of statistical thinking. However, innumeracy is prevalent even among physicians. In medical teaching the 2 × 2 table is wid...
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Article
High migration rate of two types of threaded acetabular cups
Survivorship analysis was performed on 479 Link V-type threaded cups and on 110 modified V-type Bad Bramstedt cups (a modification of the Link V-type cup since 1993 with a smaller primary coil) to evaluate the...
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Article
Role for lipid signaling and the cell integrity MAP kinase cascade in yeast septum biogenesis
Polarized deposition of chitin at the bud neck is essential for cell separation in yeast. Chitin septum biogenesis is catalyzed by two distinct chitin synthase activities encoded by the CHS2 and CHS3 genes. The ...
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Article
Asbestos exposure and malignant lymphomas – a review of the epidemiological literature
There has been a significant number of case reports on the occurrence of lymphomas in people previously exposed to asbestos. This raises the question of whether corresponding results are available from analyt...
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Article
Cholinesterases precede ”ON–OFF” channel dichotomy in the embryonic chick retina before onset of synaptogenesis
Retinal physiology is balanced by the interplay between an ON and an OFF channel. The formation of this wiring dichotomy is not understood. Two neuropil sublayers of the inner plexiform layer (IPL) represent l...
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Chapter and Conference Paper
Epidemiologische Methoden in der Arbeitsmedizin
Das Spektrum der epidemiologischen Methoden in der Arbeitsmedizin erstreckt sich von der Berechnung deskriptiver Maßzahlen bis hin zur Anwendung multivariater Modelle. Das primäre Ziel einer epidemiologischen ...
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Article
Positive phase II study in the treatment of advanced malignant melanoma with fotemustine
To date, dacarbazine (DTIC) has been the most effective drug in the treatment of advanced metastatic melanoma, achieving response rates of up to 28% (mean, 21%). Multidrug responses were generally no better th...
