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Iris M. Fink-Baldauf
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Article
Open AccessCRISPRi-mediated functional analysis of NKX2-1-binding sites in the lung
The transcription factor NKX2-1/TTF-1 is involved in lung pathophysiology, including breathing, innate defense and tumorigenesis. To understand the mechanism by which NKX2-1 regulates genes involved in such pa...
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Article
An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo
EGFR ligands (e.g., EGF and TGFA) have been shown to be clinically associated with poor survival in lung cancer. Since TGFA itself initiates autochthonous tumors in liver, breast, and pancreas but not in the l...
